苯妥英钠促进小鼠的Th2型免疫反应。
Phenytoin promotes Th2 type immune response in mice.
作者信息
Okada K, Sugiura T, Kuroda E, Tsuji S, Yamashita U
机构信息
Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
出版信息
Clin Exp Immunol. 2001 Jun;124(3):406-13. doi: 10.1046/j.1365-2249.2001.01491.x.
The effects of chronic administration of phenytoin, a common anticonvulsive drug, on immune responses were studied in mice. Anti-keyhole limpet haemocyanin (KLH) IgE antibody response after KLH-immunization was enhanced in phenytoin-treated mice. Proliferative responses of spleen cells induced with KLH, concanavalin A (ConA), lipopolysaccharide and anti-CD3 antibody were reduced in phenytoin-treated mice. Accessory function of spleen adherent cells on ConA-induced T cell proliferative response was reduced in phenytoin-treated mice. KLH-induced IL-4 production of spleen cells was enhanced, while IFN-gamma production was reduced in phenytoin-treated mice. In addition, production of IL-1 alpha, but not IL-6 and IL-12 by spleen adherent cells from phenytoin-treated mice was reduced. Natural killer cell activity was reduced in phenytoin-treated mice. These results suggest that phenytoin treatment preferentially induces a Th2 type response. We also observed that plasma ACTH and corticosterone levels were increased in phenytoin-treated mice, and speculated that phenytoin might act directly and indirectly, through HPA axis activation, on the immune system to modulate Th1/Th2 balance.
在小鼠中研究了常用抗惊厥药物苯妥英长期给药对免疫反应的影响。在经苯妥英处理的小鼠中，钥孔戚血蓝蛋白（KLH）免疫后抗KLH IgE抗体反应增强。经苯妥英处理的小鼠中，由KLH、伴刀豆球蛋白A（ConA）、脂多糖和抗CD3抗体诱导的脾细胞增殖反应降低。经苯妥英处理的小鼠中，脾黏附细胞对ConA诱导的T细胞增殖反应的辅助功能降低。经苯妥英处理的小鼠中，KLH诱导的脾细胞IL-4产生增加，而IFN-γ产生减少。此外，经苯妥英处理的小鼠脾黏附细胞产生IL-1α，但不产生IL-6和IL-12。经苯妥英处理的小鼠自然杀伤细胞活性降低。这些结果表明，苯妥英治疗优先诱导Th2型反应。我们还观察到经苯妥英处理的小鼠血浆促肾上腺皮质激素（ACTH）和皮质酮水平升高，并推测苯妥英可能通过激活下丘脑-垂体-肾上腺（HPA）轴直接和间接作用于免疫系统，以调节Th1/Th2平衡。
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