Hoffmeister-Ullerich S A
Zentrum für Molekulare Neurobiologie, University of Hamburg, Martinistrasse 52, 20246, Hamburg, Germany.
Mech Dev. 2001 Aug;106(1-2):37-45. doi: 10.1016/s0925-4773(01)00401-4.
Pedibin, a peptide of 21 amino acids, has been shown to stimulate foot formation in hydra, one of the simplest metazoan animals. The data presented here show that pedibin is synthesized as a precursor of 49 amino acids. A putative cleavage site precedes the peptide as purified from hydra tissue. The precursor, like pedibin, accelerates foot regeneration. Pedibin transcripts are concentrated in the foot region of hydra as expected, but are also present in the head region accumulating in the tentacle bases. The early appearance of pedibin transcripts during phases of cell fate specification like budding and regeneration implies that in hydra, pedibin plays an important role in patterning processes of foot and head. This is confirmed by the finding that pedibin also stimulates bud outgrowth.
Pedibin是一种由21个氨基酸组成的肽，已被证明能刺激水螅（一种最简单的后生动物）足部的形成。本文提供的数据表明，Pedibin是以一种49个氨基酸的前体形式合成的。从水螅组织中纯化得到的肽之前存在一个假定的切割位点。该前体与Pedibin一样，能加速足部再生。正如预期的那样，Pedibin转录本集中在水螅的足部区域，但也存在于头部区域，并在触手基部积累。在诸如出芽和再生等细胞命运决定阶段，Pedibin转录本的早期出现意味着在水螅中，Pedibin在足部和头部的模式形成过程中发挥着重要作用。Pedibin也能刺激芽的生长，这一发现证实了这一点。
