Waud D R, Waud B E
Anesthesiology. 1975 Jul;43(1):10-20. doi: 10.1097/00000542-197507000-00003.
The effects of repeated doses of decamethonium or succinylcholine in muscles of the cat, dog, and rabbit have been examined. In particular, the relation of degree of neuromuscular block to intensity of the electrical change at the end-plate region has been found to be more consistent when the peak spatial gradient of depolarization is used as a measure of electrical effect than when the peak depolarization is used; the reason for this difference is discussed. A plot of twitch height against electrical change provides a convenient frame of reference for following the development of phase II block quantiatively. Examples presented show that the extent and kinetics of phase II block can vary considerably among species or among muscles in a given species.
已对重复剂量的十烃季铵或琥珀酰胆碱对猫、狗和兔子肌肉的影响进行了研究。特别地，已发现，当使用去极化的峰值空间梯度作为电效应的量度时，与使用峰值去极化时相比，神经肌肉阻滞程度与终板区电变化强度之间的关系更为一致；讨论了这种差异的原因。以抽搐高度对电变化作图，为定量跟踪Ⅱ期阻滞的发展提供了一个方便的参考框架。给出的例子表明，Ⅱ期阻滞的程度和动力学在不同物种之间或给定物种的不同肌肉之间可能有很大差异。
