用于人类基因组的分区鸟枪法组装器的设计
Design of a compartmentalized shotgun assembler for the human genome.
作者信息
Huson D H, Reinert K, Kravitz S A, Remington K A, Delcher A L, Dew I M, Flanigan M, Halpern A L, Lai Z, Mobarry C M, Sutton G G, Myers E W
机构信息
Informatics Research, Celera Genomics, 45 West Gude Drive, Rockville 20850, USA.
出版信息
Bioinformatics. 2001;17 Suppl 1:S132-9. doi: 10.1093/bioinformatics/17.suppl_1.s132.
Two different strategies for determining the human genome are currently being pursued: one is the "clone-by-clone" approach, employed by the publicly funded project, and the other is the "whole genome shotgun assembler" approach, favored by researchers at Celera Genomics. An interim strategy employed at Celera, called compartmentalized shotgun assembly, makes use of preliminary data produced by both approaches. In this paper we describe the design, implementation and operation of the "compartmentalized shotgun assembler".
目前正在采用两种不同的策略来测定人类基因组
一种是由公共资助项目采用的“逐个克隆”方法，另一种是赛莱拉基因组公司的研究人员所青睐的“全基因组鸟枪法装配”方法。赛莱拉采用的一种临时策略称为分区鸟枪法装配，它利用了这两种方法产生的初步数据。在本文中，我们描述了“分区鸟枪法装配器”的设计、实现和操作。
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