用于细菌人工染色体克隆指纹图谱绘制和鸟枪法测序的广义间隙模型
Generalized gap model for bacterial artificial chromosome clone fingerprint mapping and shotgun sequencing.
作者信息
Wendl Michael C, Waterston Robert H
机构信息
Washington University School of Medicine, St. Louis, Missouri 63108, USA.
出版信息
Genome Res. 2002 Dec;12(12):1943-9. doi: 10.1101/gr.655102.
Abstract
We develop an extension to the Lander-Waterman theory for characterizing gaps in bacterial artificial chromosome fingerprint mapping and shotgun sequencing projects. It supports a larger set of descriptive statistics and is applicable to a wider range of project parameters. We show that previous assertions regarding inconsistency of the Lander-Waterman theory at higher coverages are incorrect and that another well-known but ostensibly different model is in fact the same. The apparent paradox of infinite island lengths is resolved. Several applications are shown, including evolution of the probability density function, calculation of closure probabilities, and development of a probabilistic method for computing stopping points in bacterial artificial chromosome shotgun sequencing.
摘要
我们对兰德-沃特曼理论进行了扩展，用于描述细菌人工染色体指纹图谱绘制和鸟枪法测序项目中的缺口。它支持更多种类的描述性统计，并且适用于更广泛的项目参数范围。我们表明，之前关于兰德-沃特曼理论在高覆盖率下不一致的断言是不正确的，而且另一个广为人知但表面上不同的模型实际上是相同的。无限岛长度的明显悖论得到了解决。展示了几个应用，包括概率密度函数的演变、封闭概率的计算，以及开发一种用于计算细菌人工染色体鸟枪法测序中终止点的概率方法。
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