蝙蝠葛中的细胞毒性氧化异阿朴菲生物碱。

Cytotoxic oxoisoaporphine alkaloids from Menispermum dauricum.

作者信息

Yu B W, Meng L H, Chen J Y, Zhou T X, Cheng K F, Ding J, Qin G W

机构信息

Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, People's Republic of China.

出版信息

J Nat Prod. 2001 Jul;64(7):968-70. doi: 10.1021/np000532t.

DOI:10.1021/np000532t

PMID:11473438

Abstract

Four new oxoisoaporphine alkaloids, daurioxoisoporphines A-D (1-4), were isolated from the rhizomes of Menispermum dauricum. The structures of these alkaloids were established by spectroscopic methods. The cytotoxic evaluation of 1 and 2 is reported against four cancer cell lines.

摘要

从蝙蝠葛的根茎中分离出四种新的氧化异阿朴啡生物碱，即蝙蝠葛氧化异阿朴啡A-D（1-4）。通过光谱方法确定了这些生物碱的结构。报道了化合物1和2对四种癌细胞系的细胞毒性评价。