Kuo Ping-Chung, Shi Li-Shian, Damu Amooru G, Su Chung-Ren, Huang Chieh-Hung, Ke Chih-Huang, Wu Jin-Bin, Lin Ai-Jeng, Bastow Kenneth F, Lee Kuo-Hsiung, Wu Tian-Shung
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, Republic of China.
J Nat Prod. 2003 Oct;66(10):1324-7. doi: 10.1021/np030277n.
Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.
从长叶刺蒺藜根中分离出3个新的（正戊基β-咔啉-1-丙酸酯（1）、5-羟甲基-9-甲氧基-6-酮基铁屎米（2）和1-羟基-9-甲氧基-6-酮基铁屎米（3））以及19个已知的β-咔啉生物碱。通过对它们的一维和二维核磁共振及质谱数据进行综合分析并经化学转化确定了新结构。对这些化合物进行了体外细胞毒性和抗疟活性筛选，9-甲氧基-6-酮基铁屎米（4）和6-酮基铁屎米（5）对人肺癌（A-549）和人乳腺癌（MCF-7）细胞系显示出显著的细胞毒性。
