Khan F A, Guarneri J J, Sierra M F
Am Rev Respir Dis. 1975 Jul;112(1):119-23. doi: 10.1164/arrd.1975.112.1.119.
A 48-year old, retired mounted policeman was followed for 4 years through 4 hospitalizations for progression of his bilateral, cavitary lung disease. His sputum was always negative for acid-fast bacilli and fungi. Subsequently, a painful perianal swelling appeared that was incised and drained of purulent material. Five years after first seen, sputum and rectal drainage revealed Sporothrichum schenckii in many cultures. Serologic evidence of sporotrichosis was also present. With amphotericin B therapy, the patient showed marked clinical improvement. Unfortunately, he died from an episode of acute respiratory failure. Although most patients with primary cutaneous or primary pulmonary sporotrichosis are horticulturists, the writers believe that this disease should be considered in any undiagnosed, chronic, cavitary lung disease, even in the absence of this occupational history.
一名48岁的退休骑警因双侧空洞性肺病进展，4年间4次住院接受治疗。其痰液中抗酸杆菌和真菌检测始终呈阴性。随后，出现肛周疼痛性肿胀，切开后有脓性物质引流。初诊5年后，痰液和直肠引流物多次培养显示申克孢子丝菌。同时也有孢子丝菌病的血清学证据。接受两性霉素B治疗后，患者临床症状明显改善。不幸的是，他死于一次急性呼吸衰竭发作。尽管大多数原发性皮肤或原发性肺孢子丝菌病患者是园艺工作者，但作者认为，对于任何未确诊的慢性空洞性肺病，即使没有这种职业病史，也应考虑到这种疾病。
