Gautier M, Hayes H, Taourit S, Laurent P, Eggen A
Laboratoire de Génétique biochimique et de Cytogénétique, Département de Génétique Animale, INRA-CRJ, 78350 Jouy-en-Josas, France.
Cytogenet Cell Genet. 2001;93(1-2):60-4. doi: 10.1159/000056950.
A comparative mapping approach was applied in order to refine the extent and the distribution of conserved segments between human chromosome 11 (HSA11) and cattle chromosomes 15 and 29 (BTA15 and BTA29 respectively). Eight genes from HSA11 were mapped using a bovine-hamster somatic cell hybrid panel and seven represent new assignments. Adding these assignments to those present in human, mouse and cattle databases, a new conserved segment was identified between the telomeric region of HSA11 and BTA29. This brings to seven the number of conserved segments identified between HSA11 and BTA15 and 29, and our study refines their boundaries to the level of the human cytogenetic band.
为了细化人类11号染色体（HSA11）与牛的15号和29号染色体（分别为BTA15和BTA29）之间保守片段的范围和分布，采用了一种比较图谱绘制方法。利用牛-仓鼠体细胞杂交板对HSA11上的8个基因进行了定位，其中7个代表新的定位。将这些定位结果添加到人类、小鼠和牛的数据库中已有的定位结果中，在HSA11的端粒区域和BTA29之间鉴定出一个新的保守片段。这使得在HSA11与BTA15和BTA29之间鉴定出的保守片段数量增加到7个，并且我们的研究将它们的边界细化到了人类细胞遗传学带的水平。
