痛风作为巴特综合征的一种并发症。碱中毒在尿酸清除率降低中可能起到的作用。

Gout as a complication of Bartter's syndrome. A possible role for alkalosis in the decreased clearance of uric acid.

作者信息

Meyer W J, Gill J R, Bartter F C

出版信息

Ann Intern Med. 1975 Jul;83(1):56-9. doi: 10.7326/0003-4819-83-1-56.

Abstract

A prevalence of hyperuricemia of 50% and of acute gouty arthritis of 20% has been observed in a group of patients with Bartter's syndrome. All patients except one presented initially with complaints unrelated to uric acid metabolism. The cause of their hyperuricemia and subnormal clearance of uric acid is unexplained. Systemic alkalosis, a prominent feature of Bartter's syndrome, can decrease the clearance of uric acid and may contribute to the hyperuricemia and gout that have been observed. Physicians should be aware of the possibility of gout as a clinical complication of Bartter's syndrome and of the inhibitory effects of alkalosis on urate clearance.

摘要

在一组巴特综合征患者中，观察到高尿酸血症患病率为50%，急性痛风性关节炎患病率为20%。除一名患者外，所有患者最初出现的症状均与尿酸代谢无关。他们高尿酸血症和尿酸清除率低于正常水平的原因尚不清楚。全身碱中毒是巴特综合征的一个显著特征，可降低尿酸清除率，可能导致已观察到的高尿酸血症和痛风。医生应意识到痛风作为巴特综合征临床并发症的可能性，以及碱中毒对尿酸盐清除的抑制作用。