doPico G A, Rankin J, Chosy L W, Reddan W G, Barbee R A, Gee B, Dickie H A
Ann Intern Med. 1975 Aug;83(2):177-84. doi: 10.7326/0003-4819-83-2-177.
An outbreak of upper and lower respiratory tract inflammatory disease and conjunctivitis among synthetic rubber tire workers occurred. The outbreak began after the introduction of a new thermosetting resin, containing resorcinol and a trimere of methylene aminoacetronitrile, into the rubber tire carcass stock formulation. Two hundred ten workers were affected. Characteristically, symptoms improved during periods of sick leave or vacation, recurring upon the workers' return to the plant. Chest radiograms disclosed pneumonic infiltrates in about one fourth of the cases. Pulmonary function studies detected abnormal airways dynamics as well as abnormal diffusing capacity in more than one third of the workers tested. Lung biopsy showed evidence of focal interstitial fibrosis and peribronchiolar and perivascular chronic inflammatory reaction. The illness was ascribed to volatile products released during the manufacture of synthetic rubber tires. The exact chemical nature of these products is unknown.
合成橡胶轮胎工人中爆发了上、下呼吸道炎症性疾病和结膜炎。此次疫情始于一种新的热固性树脂被引入橡胶轮胎胎体胶料配方中，该树脂含有间苯二酚和亚甲基氨基乙腈三聚体。210名工人受到影响。其特点是，症状在病假或休假期间有所改善，工人返回工厂后复发。胸部X光片显示约四分之一的病例有肺部浸润。肺功能研究发现，超过三分之一接受测试的工人存在气道动力学异常以及弥散能力异常。肺活检显示有局灶性间质纤维化以及支气管周围和血管周围慢性炎症反应的证据。该病归因于合成橡胶轮胎制造过程中释放的挥发性产物。这些产物的确切化学性质尚不清楚。
