Bascom R, Fisher J F, Thomas R J, Yang W N, Baser M E, Baker J H
Center for Occupational and Environmental Health, Johns Hopkins Medical Institutions, Wyman Park Health System, Baltimore.
Chest. 1988 Jan;93(1):154-8. doi: 10.1378/chest.93.1.154.
This report describes a spectrum of respiratory illnesses associated with eosinophilia which occurred in a group of workers exposed to fumes from a synthetic rubber-based curing operation. Respiratory syndromes induced by this exposure included an acute sensitizing illness with dyspnea and wheezing in some workers and pulmonary infiltrates with eosinophilia in others. Another worker developed chronic obstruction of the airways with recurrent bronchitic illnesses. Mild to marked peripheral eosinophilia, up to 3,000/cu mm, was usually present in the symptomatic workers and in 11 of 30 asymptomatic workers. These cases illustrate the diversity of respiratory illnesses which may result from a common workplace exposure and reinforce the importance of considering occupational exposures in the differential diagnosis of peripheral eosinophilia.
本报告描述了一组接触合成橡胶硫化作业产生烟雾的工人中发生的一系列与嗜酸性粒细胞增多相关的呼吸道疾病。这种接触引起的呼吸道综合征包括一些工人出现的伴有呼吸困难和喘息的急性致敏性疾病，以及另一些工人出现的伴有嗜酸性粒细胞增多的肺部浸润。另一名工人发展为患有复发性支气管炎的慢性气道阻塞。有症状的工人以及30名无症状工人中的11人通常存在轻度至重度外周血嗜酸性粒细胞增多，高达3000/立方毫米。这些病例说明了常见工作场所接触可能导致的呼吸道疾病的多样性，并强化了在周围血嗜酸性粒细胞增多的鉴别诊断中考虑职业接触的重要性。
