成人特发性血小板减少性紫癜患者风疹病毒和水痘-带状疱疹病毒双重感染所致病毒相关噬血细胞综合征
Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura.
作者信息
Takeoka Y, Hino M, Oiso N, Nishi S, Koh K R, Yamane T, Ohta K, Nakamae H, Aoyama Y, Hirose A, Fujino H, Takubo T, Inoue T, Tatsumi N
机构信息
Department of Clinical Hematology, Osaka City University Medical School, Japan.
出版信息
Ann Hematol. 2001 Jun;80(6):361-4. doi: 10.1007/s002770000282.
A 26-year-old woman with idiopathic thrombocytopenic purpura (ITP) was admitted to our hospital because of fever and rash. Blood tests revealed thrombocytopenia, liver dysfunction, coagulopathy, and hyperferritinemia. Bone marrow examination revealed many atypical lymphocytes and some histiocytes with hemophagocytosis. On admission she was diagnosed with rubella virus-associated hemophagocytic syndrome (VHAS), but on laboratory examination, she was seropositive for varicella-zoster virus (VZV)-IgM as well as rubella virus-IgM. She was therefore diagnosed with dual infection by rubella virus and VZV. Her simultaneous rubella virus and VZV infection may have been related to the VAHS pathogenesis. She was treated with prednisolone and gamma globulin therapy and recovered completely.
一名26岁患有特发性血小板减少性紫癜（ITP）的女性因发热和皮疹入住我院。血液检查显示血小板减少、肝功能障碍、凝血功能障碍和高铁蛋白血症。骨髓检查发现许多非典型淋巴细胞和一些具有噬血细胞作用的组织细胞。入院时她被诊断为风疹病毒相关噬血细胞综合征（VHAS），但实验室检查显示，她水痘 - 带状疱疹病毒（VZV）-IgM以及风疹病毒 - IgM均为血清阳性。因此，她被诊断为风疹病毒和VZV双重感染。她同时感染风疹病毒和VZV可能与VAHS的发病机制有关。她接受了泼尼松龙和丙种球蛋白治疗并完全康复。
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