托酚酮的抗菌活性。
Antibacterial activity of tropolone.
作者信息
Trust T J
出版信息
Antimicrob Agents Chemother. 1975 May;7(5):500-6. doi: 10.1128/AAC.7.5.500.
Abstract
Tropolone was shown to be bacteriostatic and bactericidal for a wide range of bacterial species. This antibacterial activity was quantitated using standard methods. Tropolone treatment of whole cells resulted in cell lysis characterized by bleb formation and subsequent loss of cell contents after rupture of the bleb. Although bleb formation and lysis did not occur in the presence of 20% sucrose, cell viability was lost. Spheroplasts and protoplasts also lysed in the presence of tropolone. These results indicate that tropolone acts on the cell wall or envelope and on the plasma membrane.
摘要
托酚酮对多种细菌具有抑菌和杀菌作用。这种抗菌活性采用标准方法进行定量测定。用托酚酮处理完整细胞会导致细胞裂解，其特征为形成气泡，气泡破裂后细胞内容物随之流失。尽管在20%蔗糖存在的情况下不会形成气泡和裂解，但细胞活力仍会丧失。原生质球和原生质体在托酚酮存在的情况下也会裂解。这些结果表明，托酚酮作用于细胞壁或包膜以及质膜。
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