头孢唑林和头孢噻吩在人体静脉注射和肌肉注射后血药浓度及尿排泄数据的药代动力学解释
Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans.
作者信息
Rattie E S, Ravin L J
出版信息
Antimicrob Agents Chemother. 1975 May;7(5):606-13. doi: 10.1128/AAC.7.5.606.
Abstract
Blood levels of cefazolin and cephalothin were determined in two separate crossover studies in 20 healthy male adults, each after intravenous and intramuscular administration. Pharmacokinetic parameters were calculated from the intravenous data based upon a two-compartment open model. The rate constants controlling the distribution between the central and peripheral compartments, the overall elimination rate constants, the apparent volumes of distribution, and the fraction of the dose in the central and peripheral compartments were determined. The bioavailability was calculated to be 100% for cefazolin and cephalothin.
摘要
在两项独立的交叉研究中，对20名健康成年男性分别进行静脉注射和肌肉注射后，测定了头孢唑林和头孢噻吩的血药浓度。根据二室开放模型，从静脉注射数据计算药代动力学参数。确定了控制中央室和周边室之间分布的速率常数、总消除速率常数、表观分布容积以及中央室和周边室中药物剂量的分数。计算得出头孢唑林和头孢噻吩的生物利用度均为100%。
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