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Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans.头孢唑林和头孢噻吩在人体静脉注射和肌肉注射后血药浓度及尿排泄数据的药代动力学解释
Antimicrob Agents Chemother. 1975 May;7(5):606-13. doi: 10.1128/AAC.7.5.606.
2
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Biliary tract excretion of cefazolin, cephalothin, and cephaloridine in the presence of biliary tract disease.胆道疾病存在时头孢唑林、头孢噻吩和头孢噻啶的胆道排泄
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Effects of general and local anesthesia on the pharmacokinetics of cefazolin in patients undergoing orthopedic surgery.全身麻醉和局部麻醉对骨科手术患者头孢唑林药代动力学的影响。
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本文引用的文献

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Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.将人体视为具有单室性质进行药代动力学分析时存在的缺点。
J Pharm Sci. 1968 Jan;57(1):117-23. doi: 10.1002/jps.2600570123.
2
Pharmacokinetics of the cephalosporins in healthy volunteers and uremic patients.头孢菌素类药物在健康志愿者和尿毒症患者体内的药代动力学。
Postgrad Med J. 1971 Feb;47:Suppl:41-6.
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Cephalosporin antibiotics: therapeutic dimensions and future.
Postgrad Med J. 1971 Feb;47:Suppl:135-42.
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Cefazolin, a new semisynthetic cephalosporin antibiotic. I. Synthesis and chemical properties of cefazolin.头孢唑林，一种新型半合成头孢菌素抗生素。I.头孢唑林的合成及化学性质。
J Antibiot (Tokyo). 1970 Mar;23(3):131-6. doi: 10.7164/antibiotics.23.131.
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Cefazolin, a new semisynthetic cephalosporin antibiotic. 3. Absorption, excretion and tissue distribution in parenteral administration.头孢唑林，一种新型半合成头孢菌素抗生素。3. 胃肠外给药的吸收、排泄及组织分布。
J Antibiot (Tokyo). 1970 Apr;23(4):184-94.
6
Biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics.三种3-杂环硫甲基头孢菌素抗生素的生物学特性
Antimicrob Agents Chemother. 1972 Mar;1(3):221-34. doi: 10.1128/AAC.1.3.221.
7
Cefazolin vs cephalothin and cephaloridine. A comparison of their clinical pharmacology.头孢唑林与头孢噻吩及头孢噻啶的比较。它们临床药理学的对比
Arch Intern Med. 1974 Mar;133(3):407-10.
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Pharmacologic study of cefazolin in volunteers.
J Clin Pharmacol New Drugs. 1973 Feb-Mar;13(2):83-8. doi: 10.1002/j.1552-4604.1973.tb00257.x.
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Comparative serum levels and urinary recovery of cefazolin, cephaloridine, and cephalothin in man.头孢唑林、头孢噻啶和头孢噻吩在人体中的血清水平及尿液回收率比较
J Clin Pharmacol. 1974 Jan;14(1):61-6. doi: 10.1002/j.1552-4604.1974.tb02289.x.
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Cefazolin, a new semisynthetic cephalosporin antibiotic. II. In vitro and in vivo antimicrobial activity.
J Antibiot (Tokyo). 1970 Mar;23(3):137-48. doi: 10.7164/antibiotics.23.137.

头孢唑林和头孢噻吩在人体静脉注射和肌肉注射后血药浓度及尿排泄数据的药代动力学解释

Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans.

作者信息

Rattie E S, Ravin L J

出版信息

Antimicrob Agents Chemother. 1975 May;7(5):606-13. doi: 10.1128/AAC.7.5.606.

DOI:10.1128/AAC.7.5.606
PMID:1147591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429190/
Abstract

Blood levels of cefazolin and cephalothin were determined in two separate crossover studies in 20 healthy male adults, each after intravenous and intramuscular administration. Pharmacokinetic parameters were calculated from the intravenous data based upon a two-compartment open model. The rate constants controlling the distribution between the central and peripheral compartments, the overall elimination rate constants, the apparent volumes of distribution, and the fraction of the dose in the central and peripheral compartments were determined. The bioavailability was calculated to be 100% for cefazolin and cephalothin.

摘要

在两项独立的交叉研究中，对20名健康成年男性分别进行静脉注射和肌肉注射后，测定了头孢唑林和头孢噻吩的血药浓度。根据二室开放模型，从静脉注射数据计算药代动力学参数。确定了控制中央室和周边室之间分布的速率常数、总消除速率常数、表观分布容积以及中央室和周边室中药物剂量的分数。计算得出头孢唑林和头孢噻吩的生物利用度均为100%。