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Effects of general and local anesthesia on the pharmacokinetics of cefazolin in patients undergoing orthopedic surgery.全身麻醉和局部麻醉对骨科手术患者头孢唑林药代动力学的影响。
Antimicrob Agents Chemother. 1985 May;27(5):874-5. doi: 10.1128/AAC.27.5.874.
2
Cefazolin concentrations in bone and synovial fluid.
J Bone Joint Surg Am. 1978 Apr;60(3):359-62.
3
Pharmacokinetics of moxalactam and cefazolin compared in normal volunteers.正常志愿者中莫西拉坦与头孢唑林的药代动力学比较。
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Cefazolin and netilmicin serum levels during and after cardiac surgery with cardiopulmonary bypass.体外循环心脏手术期间及术后头孢唑林和奈替米星的血清水平。
J Cardiothorac Anesth. 1990 Apr;4(2):204-9. doi: 10.1016/0888-6296(90)90239-c.
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The penetration characteristics of cefazolin, cephalothin, and cephradine into bone in patients undergoing total hip replacement.
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Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus.阳离子抗菌肽 LL-37 对金黄色葡萄球菌的胞外和胞内均有效。
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本文引用的文献

1
Penetration of cephalosporins into bone.
Infection. 1984 Mar-Apr;12(2):80-4. doi: 10.1007/BF01641676.
2
Moxalactam and cefazolin: comparative pharmacokinetics in normal subjects.羟羧氧酰胺菌素和头孢唑林：正常受试者体内的比较药代动力学
Antimicrob Agents Chemother. 1981 Apr;19(4):613-9. doi: 10.1128/AAC.19.4.613.
3
Evaluation of cefazolin, a new cephalosporin antibiotic.新型头孢菌素抗生素头孢唑林的评估
Antimicrob Agents Chemother. 1973 Apr;3(4):488-97. doi: 10.1128/AAC.3.4.488.
4
Pharmacology of cefazolin in human volunteers.
J Clin Pharmacol. 1973 Aug-Sep;13(8):325-31. doi: 10.1002/j.1552-4604.1973.tb00219.x.
5
Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans.头孢唑林和头孢噻吩在人体静脉注射和肌肉注射后血药浓度及尿排泄数据的药代动力学解释
Antimicrob Agents Chemother. 1975 May;7(5):606-13. doi: 10.1128/AAC.7.5.606.
6
Changes in pharmacokinetics of cefazolin due to stress.应激导致的头孢唑啉药代动力学变化。
J Pharm Sci. 1975 Apr;64(4):712-4. doi: 10.1002/jps.2600640437.
7
The penetration characteristics of cefazolin, cephalothin, and cephradine into bone in patients undergoing total hip replacement.
J Bone Joint Surg Am. 1977 Oct;59(7):856-9.

全身麻醉和局部麻醉对骨科手术患者头孢唑林药代动力学的影响。

Effects of general and local anesthesia on the pharmacokinetics of cefazolin in patients undergoing orthopedic surgery.

作者信息

Welch W D, Jantzen J P, Johnson K, Bawdon R E

出版信息

Antimicrob Agents Chemother. 1985 May;27(5):874-5. doi: 10.1128/AAC.27.5.874.

DOI:10.1128/AAC.27.5.874
PMID:4015078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180170/
Abstract

The pharmacokinetics of cefazolin in patients undergoing orthopedic surgery with either general (enflurane) or local (lidocaine or marcaine) anesthesia were studied. No differences in either mean serum levels at 30, 60, or 120 min after the intravenous injection of cefazolin or serum half-lives were seen between the two groups of patients.

摘要

对接受全身麻醉（恩氟烷）或局部麻醉（利多卡因或布比卡因）的骨科手术患者进行了头孢唑林的药代动力学研究。两组患者在静脉注射头孢唑林后30、60或120分钟时的平均血清水平或血清半衰期均无差异。