全身麻醉和局部麻醉对骨科手术患者头孢唑林药代动力学的影响。
Effects of general and local anesthesia on the pharmacokinetics of cefazolin in patients undergoing orthopedic surgery.
作者信息
Welch W D, Jantzen J P, Johnson K, Bawdon R E
出版信息
Antimicrob Agents Chemother. 1985 May;27(5):874-5. doi: 10.1128/AAC.27.5.874.
Abstract
The pharmacokinetics of cefazolin in patients undergoing orthopedic surgery with either general (enflurane) or local (lidocaine or marcaine) anesthesia were studied. No differences in either mean serum levels at 30, 60, or 120 min after the intravenous injection of cefazolin or serum half-lives were seen between the two groups of patients.
摘要
对接受全身麻醉（恩氟烷）或局部麻醉（利多卡因或布比卡因）的骨科手术患者进行了头孢唑林的药代动力学研究。两组患者在静脉注射头孢唑林后30、60或120分钟时的平均血清水平或血清半衰期均无差异。
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