Rennen H J, Corstens F H, Oyen W J, Boerman O C
Department of Nuclear Medicine, University Medical Center, Nijmegen, The Netherlands.
Q J Nucl Med. 2001 Jun;45(2):167-73.
Although autologous leukocytes, labelled with 111In or 99mTc, is still considered the "gold standard" nuclear medicine technique to image infection and inflammation, there is a great need for a less cumbersome and less hazardous approach. Over the last few decades the range of radiopharmaceuticals to investigate infectious and non-microbial inflammatory disorders is vastly expanding. Radiolabelled monoclonal antibodies and antibody-fragments, radiolabelled chemotactic peptides and cytokines, and radiolabelled antibiotics are promising new approaches in the field of nuclear medicine. Recently, positron emission tomography (PET) with 18FJDG has been introduced and has been shown to delineate infectious and inflammatory foci with high sensitivity. Here, a survey is presented of the different approaches in use or under investigation.
尽管用铟 - 111或锝 - 99m标记的自体白细胞仍然被认为是用于感染和炎症成像的“金标准”核医学技术，但人们迫切需要一种更简便且危害更小的方法。在过去几十年里，用于研究感染性和非微生物炎症性疾病的放射性药物种类正在大幅增加。放射性标记的单克隆抗体和抗体片段、放射性标记的趋化肽和细胞因子以及放射性标记的抗生素是核医学领域有前景的新方法。最近，18F - FDG正电子发射断层扫描（PET）已被引入，并已被证明能以高灵敏度描绘感染和炎症病灶。在此，对正在使用或正在研究的不同方法进行综述。
