Boerman O C, Dams E T, Oyen W J, Corstens F H, Storm G
Dept. Nuclear Medicine, University Medical Centre Nijmegen, The Netherlands.
Inflamm Res. 2001 Feb;50(2):55-64. doi: 10.1007/s000110050725.
Scintigraphic imaging of infection and inflammation is a powerful diagnostic tool in the management of patients with infectious or inflammatory diseases. Most infectious and inflammatory foci can be visualized accurately with radiolabeled autologous leukocytes. However, preparation of this radiopharmaceutical is laborious and requires the handling of potentially contaminated blood. Nowadays, a few radiopharmaceuticals are available that could replace radiolabeled leukocytes, such as: 67Ga-citrate, 99mTc-IgG and 99mTc-labeled antigranulocyte antibody preparations. Furthermore, various agents labeled with 99mTc are currently developed for this application: chemotactic peptides, cytokines and liposomes. Here, the characteristics and the diagnostic potential of established and experimental radiopharmaceuticals for infection and inflammation imaging are reviewed.
感染与炎症的闪烁成像在感染性或炎症性疾病患者的管理中是一种强大的诊断工具。大多数感染性和炎症病灶可用放射性标记的自体白细胞准确显像。然而，这种放射性药物的制备过程繁琐，且需要处理可能被污染的血液。如今，有几种放射性药物可替代放射性标记的白细胞，例如：枸橼酸镓-67、锝-99m标记的免疫球蛋白和锝-99m标记的抗粒细胞抗体制剂。此外，目前正在研发各种用锝-99m标记的用于该应用的试剂：趋化肽、细胞因子和脂质体。在此，对用于感染与炎症成像的已确立和实验性放射性药物的特性及诊断潜力进行综述。
