糖尿病患者初次全膝关节置换术中使用头孢呋辛浸渍骨水泥：一项前瞻性随机研究。

Cefuroxime-impregnated cement at primary total knee arthroplasty in diabetes mellitus. A prospective, randomised study.

作者信息

Chiu F Y, Lin C F, Chen C M, Lo W H, Chaung T Y

机构信息

Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital and the National Yang-Mang University, Taiwan, Republic of China.

出版信息

J Bone Joint Surg Br. 2001 Jul;83(5):691-5. doi: 10.1302/0301-620x.83b5.11737.

DOI:10.1302/0301-620x.83b5.11737

PMID:11476307

Abstract

We have performed a prospective single-blinded randomised study to evaluate the role of antibiotic-impregnated cement in the prevention of deep infection at primary total knee arthroplasty (TKA) in patients with diabetes mellitus. We studied prospectively 78 arthroplasties performed for osteoarthritis in such patients. They were randomly separated into two groups. In group 1 (41 knees), cefuroxime-impregnated cement was used while in group 2 (37 knees) cefuroxime was not added to the cement. The preoperative, intraoperative and postoperative management was the same for both groups. The mean follow-up was 50 months (26 to 88). There were no cases of deep infection in group 1, but five (13.5%) occurred in group 2 (p = 0.021). We conclude that cefuroxime-impregnated cement is effective in the prevention of deep infection at primary TKA in patients with diabetes mellitus.

摘要

我们进行了一项前瞻性单盲随机研究，以评估抗生素骨水泥在预防糖尿病患者初次全膝关节置换术（TKA）深部感染中的作用。我们前瞻性地研究了78例为此类患者进行的骨关节炎置换手术。他们被随机分为两组。第1组（41膝）使用头孢呋辛骨水泥，而第2组（37膝）的骨水泥中未添加头孢呋辛。两组的术前、术中和术后管理相同。平均随访时间为50个月（26至88个月）。第1组无深部感染病例，而第2组有5例（13.5%）发生深部感染（p = 0.021）。我们得出结论，头孢呋辛骨水泥在预防糖尿病患者初次TKA深部感染方面是有效的。