头孢呋辛在全关节置换术中的应用。静脉注射或用于骨水泥。

Cefuroxime in total joint arthroplasty. Intravenous or in bone cement.

作者信息

McQueen M M, Hughes S P, May P, Verity L

机构信息

Department of Orthopaedic Surgery, Princess Margaret Rose Orthopaedic Hospital, Fairmilehead, Edinburgh, Scotland.

出版信息

J Arthroplasty. 1990 Jun;5(2):169-72. doi: 10.1016/s0883-5403(06)80236-6.

DOI:10.1016/s0883-5403(06)80236-6

PMID:2193113

Abstract

A prospective randomized clinical trial was performed in two centers to compare the effect of systemic cefuroxime and cefuroxime in bone cement in the prophylaxis of infection after total joint arthroplasty. In two comparable groups comprising 200 and 201 patients, there was no statistically significant difference in the incidence of superficial wound infection. The early deep infection rate was 1%, with no difference detected between the group that received antibiotic in bone cement and the group that received systemic antibiotic. There were no late deep infections. It is concluded that cefuroxime given systemically or in bone cement is an effective antibiotic in the prophylaxis of infection after total joint arthroplasty.

摘要

在两个中心进行了一项前瞻性随机临床试验，以比较全身应用头孢呋辛与头孢呋辛添加于骨水泥中在全关节置换术后预防感染的效果。在两个分别包含200例和201例患者的可比组中，浅表伤口感染发生率无统计学显著差异。早期深部感染率为1%，在骨水泥中添加抗生素组与全身应用抗生素组之间未检测到差异。无晚期深部感染。结论是全身应用或添加于骨水泥中的头孢呋辛是全关节置换术后预防感染的有效抗生素。