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1
Ascorbic acid and tyrosine metabolism in preterm and small-for-dates infants.早产和小样儿体内的抗坏血酸与酪氨酸代谢
Arch Dis Child. 1975 Mar;50(3):235-7. doi: 10.1136/adc.50.3.235.
2
Tyrosinemia and tyrosyluria in healthy prematures: time courses not vitamin C-dependent.健康早产儿中的酪氨酸血症和酪氨酸尿症：病程不依赖维生素C。
Clin Chim Acta. 1975 May 15;61(1):73-90. doi: 10.1016/0009-8981(75)90399-x.
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Ascorbic acid concentrations in umbilical cord veins and arteries of preterm and term newborns.早产儿和足月儿脐带静脉和动脉中的抗坏血酸浓度。
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High plasma vitamin C concentrations at birth associated with low antioxidant status and poor outcome in premature infants.出生时血浆维生素C浓度高与早产儿抗氧化状态低及不良结局相关。
Arch Dis Child Fetal Neonatal Ed. 1994 Jul;71(1):F40-4. doi: 10.1136/fn.71.1.f40.
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THE PLASMA TYROSINE LEVELS OF PREMATURE BABIES.早产儿的血浆酪氨酸水平。
Arch Dis Child. 1964 Aug;39(206):371-8. doi: 10.1136/adc.39.206.371.
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Ascorbic acid, dehydroascorbic acid and glutathione in liver disease.肝脏疾病中的抗坏血酸、脱氢抗坏血酸和谷胱甘肽
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Increased renal net acid excretion in prematures below 1,600 g body weight compared with prematures and small-for-date newborns above 2,100 g on alimentation with a commercial preterm formula.与体重超过2100克的早产儿和小于胎龄新生儿相比，体重低于1600克的早产儿在使用市售早产配方奶喂养时，肾脏净酸排泄增加。
Biol Neonate. 1994;66(1):10-5. doi: 10.1159/000244084.
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Ascorbic acid nutritional status and tyrosine metabolism.抗坏血酸营养状况与酪氨酸代谢
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Anthropometric determinants of creatinine excretion in preterm infants.早产儿肌酐排泄的人体测量学决定因素
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Vitamin E and vitamin C plasma levels in premature infants following supplementation of vitamin C.补充维生素C后早产儿的血浆维生素E和维生素C水平
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引用本文的文献

1
Tyrosine and its metabolites in urine and serum of premature and mature newborns: increased values during formula versus breast feeding.
Eur J Pediatr. 1979 Nov;132(3):179-87. doi: 10.1007/BF00442434.

本文引用的文献

1
A DEFECT IN THE METABOLISM OF AROMATIC AMINO ACIDS IN PREMATURE INFANTS: THE ROLE OF VITAMIN C.早产儿芳香族氨基酸代谢缺陷：维生素C的作用。
Science. 1939 Dec 29;90(2348):620-1. doi: 10.1126/science.90.2348.620.
2
A new error of tyrosine metabolism: tyrosinosis. The intermediary metabolism of tyrosine and phenylalanine.酪氨酸代谢的一种新病症：酪氨酸血症。酪氨酸和苯丙氨酸的中间代谢。
Biochem J. 1932;26(4):917-40. doi: 10.1042/bj0260917.
3
THE METABOLISM OF l-TYROSINE IN INFANTILE SCURVY.婴儿坏血病中L-酪氨酸的代谢
J Clin Invest. 1950 Mar;29(3):325-35. doi: 10.1172/JCI102261.
4
A DEFECT IN THE METABOLISM OF TYROSINE AND PHENYLALANINE IN PREMATURE INFANTS. II. SPONTANEOUS OCCURRENCE AND ERADICATION BY VITAMIN C.早产儿酪氨酸和苯丙氨酸代谢缺陷。II. 维生素C的自然发生和消除作用
J Clin Invest. 1941 Mar;20(2):209-19. doi: 10.1172/JCI101213.
5
THE PLASMA TYROSINE LEVELS OF PREMATURE BABIES.早产儿的血浆酪氨酸水平。
Arch Dis Child. 1964 Aug;39(206):371-8. doi: 10.1136/adc.39.206.371.
6
The determination of ascorbic acid in white blood cells. A comparison of W.B.C. ascorbic acid and phenolic acid excretion in elderly patients.白细胞中抗坏血酸的测定。老年患者白细胞抗坏血酸与酚酸排泄的比较。
Clin Sci. 1961 Oct;21:157-62.
7
Some investigations on the metabolism of phenylalanine and tyrosine in children with vitamin C deficiency.关于维生素C缺乏儿童苯丙氨酸和酪氨酸代谢的一些研究。
Arch Dis Child. 1957 Apr;32(162):77-81. doi: 10.1136/adc.32.162.77.
8
Certain aspects of tyrosine metabolism in the young. I. The development of the tyrosine oxidizing system in human liver.幼年时期酪氨酸代谢的某些方面。I. 人肝脏中酪氨酸氧化系统的发育
J Clin Invest. 1956 Feb;35(2):236-44. doi: 10.1172/JCI103268.
9
Tyrosinemia and tyrosinuria in low-birth-weight infants. A new criterion to assess maturity at birth.低体重儿中的酪氨酸血症和酪氨酸尿症。一种评估出生时成熟度的新标准。
Am J Dis Child. 1971 Feb;121(2):182-5. doi: 10.1001/archpedi.1971.02100130136019.
10
Tyrosinemia and tyrosinuria in low birth weight infants in India.印度低体重婴儿中的酪氨酸血症和酪氨酸尿症
Indian Pediatr. 1972 Nov;9(11):703-6.

早产和小样儿体内的抗坏血酸与酪氨酸代谢

Ascorbic acid and tyrosine metabolism in preterm and small-for-dates infants.

作者信息

Mohanram M, Kumar A

出版信息

Arch Dis Child. 1975 Mar;50(3):235-7. doi: 10.1136/adc.50.3.235.

DOI:10.1136/adc.50.3.235
PMID:1147657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1544508/
Abstract

Ascorbic acid levels in plasma and leucocytes and urinary excretion of tyrosyl derivatives (TD) were determined in 11 normal, 18 preterm, and 4 small-for-dates infants. Concentrations of ascorbic acid in both plasma and leucocytes were found to be similar in the 3 groups. There was no difference in the basal levels of TD between normal and small-for-dates infants, but preterms showed higher basal excretion of TD than the other two groups. After protein load the excretion of TD was higher than the basal level in preterms. It was concluded that the altered metabolism of tyrosine observed in preterms is not the result of poor ascorbic acid status; and that tyrosine metabolism is influenced by the period of gestation rather than the body weight of the infant.

摘要

对11名正常婴儿、18名早产儿和4名小于胎龄儿测定了血浆和白细胞中的抗坏血酸水平以及酪氨酸衍生物（TD）的尿排泄量。发现三组中血浆和白细胞中的抗坏血酸浓度相似。正常婴儿和小于胎龄儿之间TD的基础水平没有差异，但早产儿的TD基础排泄量高于其他两组。蛋白质负荷后，早产儿TD的排泄量高于基础水平。得出的结论是，早产儿中观察到的酪氨酸代谢改变不是抗坏血酸状态不佳的结果；并且酪氨酸代谢受妊娠期影响，而非婴儿体重的影响。