出生时血浆维生素C浓度高与早产儿抗氧化状态低及不良结局相关。
High plasma vitamin C concentrations at birth associated with low antioxidant status and poor outcome in premature infants.
作者信息
Silvers K M, Gibson A T, Powers H J
机构信息
University Department of Paediatrics, University of Sheffield.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1994 Jul;71(1):F40-4. doi: 10.1136/fn.71.1.f40.
Concentrations of circulating antioxidants may be important in the aetiology of disease in premature infants. Blood samples were taken from 49 premature infants within two hours of birth. Plasma ascorbic acid, caeruloplasmin, and the ability of plasma to prevent lipid peroxidation in vitro were measured. Plasma ascorbic acid concentrations at birth ranged from 26.3 to 185.4 mumol/l. Plasma antioxidant activity at birth (microliter plasma required to inhibit lipid peroxidation) showed a strong negative correlation with plasma ascorbic acid and the plasma ascorbic acid to caeruloplasmin ratio. After correcting for gestational age and birth weight, plasma antioxidant activity at birth remained a significant predictor of mortality. Such plasma antioxidant activity is partly determined by the ferroxidase activity of caeruloplasmin. This may be modulated by high concentrations of ascorbic acid which may inhibit the antioxidant activity of plasma and thereby influence outcome.
循环抗氧化剂的浓度可能在早产儿疾病的病因学中起重要作用。在出生后两小时内从49名早产儿采集血样。测量血浆中的抗坏血酸、铜蓝蛋白以及血浆在体外防止脂质过氧化的能力。出生时血浆抗坏血酸浓度范围为26.3至185.4微摩尔/升。出生时血浆抗氧化活性（抑制脂质过氧化所需的微升血浆）与血浆抗坏血酸以及血浆抗坏血酸与铜蓝蛋白的比值呈强烈负相关。在校正胎龄和出生体重后，出生时的血浆抗氧化活性仍然是死亡率的重要预测指标。这种血浆抗氧化活性部分由铜蓝蛋白的铁氧化酶活性决定。高浓度的抗坏血酸可能会对其产生调节作用，抗坏血酸可能会抑制血浆的抗氧化活性，从而影响结局。
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