Leihy M W, Shaw G, Wilson J D, Renfree M B
Department of Zoology, University of Melbourne, Victoria 3010, Parkville, Australia.
Mol Cell Endocrinol. 2001 Jul 5;181(1-2):111-5. doi: 10.1016/s0303-7207(01)00527-5.
The androgen 5alpha-androstane-3alpha,17beta-diol (5alpha-adiol) is synthesized in testes and secreted into plasma of male tammar wallaby pouch young and appears to virilize the urogenital sinus. To provide insight into its mechanism of action, a dose response study showed that administration of 1 microg 5alpha-adiol monoenanthate per g body wt. per week for 3 weeks to 24-day-old female pouch young induced prostate bud formation equivalent to that of males of the same age. Administration of this same dose of the enanthates of testosterone, dihydrotestosterone, and 5alpha-adiol to female pouch young caused equivalent virilization of the urogenital sinus. The fact that 5alpha-adiol does not exert a unique effect, together with our earlier findings in this species that 5alpha-adiol and testosterone are converted to dihydrotestosterone in the urogenital sinus and that virilization of the urogenital sinus is prevented by the androgen receptor antagonist flutamide, suggest that 5alpha-adiol is a circulating precursor for dihydrotestosterone formation in this tissue.
雄激素5α-雄烷-3α,17β-二醇（5α-二醇）在睾丸中合成，并分泌到雄性帚尾袋鼬幼崽的血浆中，似乎会使泌尿生殖窦男性化。为了深入了解其作用机制，一项剂量反应研究表明，每周每克体重给予1微克5α-二醇单庚酸酯，连续3周，对24日龄的雌性袋鼬幼崽进行给药，可诱导出与同龄雄性相当的前列腺芽形成。对雌性袋鼬幼崽给予相同剂量的睾酮、双氢睾酮和5α-二醇的庚酸酯，会导致泌尿生殖窦产生同等程度的男性化。5α-二醇并未发挥独特作用，这一事实，再加上我们早期在该物种中的发现，即5α-二醇和睾酮在泌尿生殖窦中会转化为双氢睾酮，且雄激素受体拮抗剂氟他胺可阻止泌尿生殖窦的男性化，表明5α-二醇是该组织中双氢睾酮形成的循环前体。
