哇巴因对碳酸酐酶抑制后脑脊液生成的影响。
Effect of ouabain on cerebrospinal fluid formation after carbonic anhydrase inhibition.
作者信息
Garg L C, Mathur P P
出版信息
Arch Int Pharmacodyn Ther. 1975 Feb;213(2):190-4.
The effect of ventriculo-cisternal perfusion of ouabain was determined on CSF production after inhibition of carbonic anhydrase by benzolamide in cats. An additional decrease in CSF formation was observed by combination of i.v. benzolamide and intraventricular ouabain. However, the effect of the combined drugs was less than the sum of the effects of the drugs given individually. It is concluded that the reduction of the CSF production by ouabain is probably partly due to its effect on Na-K exchange (through inhibition of Na-K-activated ATPase) and partly due to its effects on Na+ transport coupled to anion transport mediated by carbonic anhydrase.
在猫身上，研究了哇巴因脑室-脑池灌注对经苯磺酰胺抑制碳酸酐酶后脑脊液生成的影响。静脉注射苯磺酰胺和脑室内注射哇巴因联合使用时，观察到脑脊液生成进一步减少。然而，联合用药的效果小于单独用药效果之和。得出的结论是，哇巴因使脑脊液生成减少可能部分归因于其对钠钾交换的作用（通过抑制钠钾激活的ATP酶），部分归因于其对与碳酸酐酶介导的阴离子转运偶联的钠离子转运的作用。
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