Ding H, Kudo M, Onda H, Suetomi Y, Minami Y, Maekawa K
Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.
Radiology. 2001 Aug;220(2):349-56. doi: 10.1148/radiology.220.2.r01au07349.
To assess the effectiveness of contrast material-enhanced intermittent harmonic Doppler ultrasonography (US) in depicting tumor vessels and tumor parenchymal flow (stain) in hepatocellular carcinoma (HCC).
Fifty-eight patients with 65 HCC nodules were examined by using intermittent harmonic power Doppler US and digital subtraction harmonic B-mode US, both with intravenous administration of SH U 508A. Vascular findings at early arterial phase harmonic US were classified as positive enhancement or nonenhancement, depending on the tumor vascularity relative to the surrounding liver parenchyma. These results were compared with those of three-phase helical dynamic computed tomography (CT).
For hypervascular HCCs, there was excellent depiction of tumor vessels and tumor stain with the two intermittent harmonic US methods. The sensitivity and specificity for depiction of tumor vascularity were 93% (41 of 44 nodules) and 100% (21 of 21), respectively, with intermittent harmonic power Doppler US and 86% (38 of 44) and 100% (21 of 21), respectively, with subtraction US, as compared with these values at dynamic CT. Attenuation was an important factor in the depictability of tumor vascularity at harmonic US.
Contrast-enhanced intermittent harmonic US enables noninvasive demonstration of tumor vessels and especially tumor stain in HCC.
评估造影剂增强间歇谐波多普勒超声（US）在显示肝细胞癌（HCC）肿瘤血管和肿瘤实质血流（染色）方面的有效性。
58例患有65个HCC结节的患者接受了间歇谐波功率多普勒超声和数字减影谐波B型超声检查，均静脉注射SH U 508A。根据肿瘤血管相对于周围肝实质的情况，将早期动脉期谐波超声的血管表现分为阳性增强或无增强。将这些结果与三相螺旋动态计算机断层扫描（CT）的结果进行比较。
对于富血管性HCC，两种间歇谐波超声方法对肿瘤血管和肿瘤染色的显示效果极佳。与动态CT相比，间歇谐波功率多普勒超声显示肿瘤血管的敏感性和特异性分别为93%（44个结节中的41个）和100%（21个中的21个），减影超声分别为86%（44个中的38个）和100%（21个中的21个）。衰减是谐波超声显示肿瘤血管的一个重要因素。
对比增强间歇谐波超声能够无创显示HCC的肿瘤血管，尤其是肿瘤染色。
