Galati S C, Channick B J, Biddle C M, Marks A D
Arch Intern Med. 1975 Feb;135(2):260-3. doi: 10.1001/archinte.135.2.260.
Two hundred one patients with essential hypertension, who had studies of their renin-aldosterone system performed between April 1967 and December 1972, were surveyed for myocardial infraction or cerebrovascular accident. Of the patients, 42% had low plasma renin activity. Myocardial infractions or cerebrovascular accidents were documented in 15% of those with low plasms renin activity and in 5% of those with normal plasma renin activity. When adjustments were made for differences in afe and blood pressure , a protective effect in low-renin hypertension was evident. When black patients were considered separately,there was no difference in diastolic blood pressure; however, vascular complications were not less frequent in low-renin hypertensives. The results suggest that low plasma renin activity does not protect against the development of vascular complications in essential hypertension.
对1967年4月至1972年12月期间进行了肾素-醛固酮系统研究的201例原发性高血压患者进行了心肌梗死或脑血管意外调查。这些患者中，42%的人血浆肾素活性较低。血浆肾素活性低的患者中有15%发生了心肌梗死或脑血管意外，血浆肾素活性正常的患者中这一比例为5%。当对年龄和血压差异进行校正后，低肾素性高血压的保护作用明显。当单独考虑黑人患者时，舒张压没有差异；然而，低肾素性高血压患者血管并发症的发生率并不低。结果表明，血浆肾素活性低并不能预防原发性高血压患者血管并发症的发生。
