Verbovaia N I
Kardiologiia. 1977 Oct;17(10):41-5.
In 94 patients with hypertension the plasma renin activity was determined by the Yu. A. Serebrovskaya and I.A. Uchitel technique, the glomerular filtration--after Rehberg, potassium and sodium content in blood serum and 24-hour urine samples--by flame photometry. Hypertensive disease was found to be accompanied by an elevated plasma renin activity in 47.9% of the patients, by a normal level--in 26.9%, and by a reduced--in 25.6%, as compared with control group data. Cardiovascular complicatins were found in 1/5 of those with an elevated plasma renin activity, and no such complications were observed in those with a normal or reduced renin activity. An elevated plasma renin activity is a risk factor. The highest mean age and the longest duration of the disease history are typical for patients with low plasma renin activity. To choose the most rational therapy regimen it may be useful to calculate the renin-sodium index that reflects the relationship between the plasma renin activity and the urine excretion of sodium.
对94例高血压患者采用尤·阿·谢列布罗夫斯卡娅和伊·亚·乌奇特利的技术测定血浆肾素活性，采用雷伯格法测定肾小球滤过率，采用火焰光度法测定血清及24小时尿样中的钾和钠含量。与对照组数据相比，发现47.9%的患者高血压病伴有血浆肾素活性升高，26.9%的患者血浆肾素活性正常，25.6%的患者血浆肾素活性降低。血浆肾素活性升高的患者中有五分之一出现心血管并发症，而肾素活性正常或降低的患者未观察到此类并发症。血浆肾素活性升高是一个危险因素。血浆肾素活性低的患者平均年龄最高，病程最长。为选择最合理的治疗方案，计算反映血浆肾素活性与尿钠排泄之间关系的肾素-钠指数可能会有所帮助。
