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泰国儿科医生如何管理哮喘。

How pediatricians manage asthma in Thailand.

作者信息

Vichyanond P, Hatchaleelaha S, Jintavorn V, Kerdsomnuig S

机构信息

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Pediatr Pulmonol. 2001 Aug;32(2):109-14. doi: 10.1002/ppul.1096.

Abstract

Currently, there is no existing information regarding prescribing practices for the management of childhood asthma among pediatricians in Thailand. In order to evaluate the management standards for childhood asthma in Thailand, 400 self-administered questionnaires were randomly mailed to nonacademic pediatricians throughout Thailand, asking questions about their preferences in the treatment of childhood asthma. One hundred and seventy-four of these 400 questionnaires were returned (a response rate of 43.5%). Data were analyzed using the descriptive module of the Epi-info 6 program. For acute asthma, 17% of the respondents used objective measures such as peak flow meters in assessing asthma severity and severity of acute asthma attacks. The drug of first choice for treating acute attacks was a nebulized beta-agonist q 20 min (81.8%). Although 93% indicated that they had used theophylline for treating acute attacks, most would reserve the drug for patients with severe symptoms. Corticosteroids were reserved for those with severe attacks (91.7% both for clinic and for in-hospital settings). Hydrocortisone was the most preferred corticosteroid preparation (59.8%). Ninety-seven percent used antibiotics in treating acute asthma, but only with appropriate indications. For chronic asthma, a strong preference was observed for oral beta-agonists as the bronchodilator of choice (88%). For moderately severe asthmatics, theophylline was still preferred by 41% of the responders. Among prophylactic agents, ketotifen was the most favored drug (90.4%), whereas inhaled steroids and cromolyn were chosen by 9.6% and 2.4%, respectively. Eighty-five percent indicated that they would prescribe prophylactic agents for 1 year or less. Forty-two percent never considered allergy evaluation as a part of a workup for childhood asthma. Certain prescribing practices of childhood asthma management in Thailand were observed among pediatricians, i.e., 1) low frequency of using objective measures in assessing asthma severity among pediatricians; 2) frequent use of theophylline and antibiotics in the treatment of acute asthma; 3) late introduction of corticosteroids in treating acute asthma; 4) preference for oral bronchodilators; and 5) preference of ketotifen as the prophylactic drug of choice. This survey provides baseline data and will aid in the evaluation of management guidelines for childhood asthma in Thailand.

摘要

目前,泰国儿科医生在儿童哮喘管理方面的处方习惯尚无现有信息。为了评估泰国儿童哮喘的管理标准,向泰国各地的非学术型儿科医生随机邮寄了400份自填式问卷,询问他们在儿童哮喘治疗方面的偏好。这400份问卷中有174份被退回(回复率为43.5%)。使用Epi-info 6程序的描述性模块对数据进行了分析。对于急性哮喘,17%的受访者在评估哮喘严重程度和急性哮喘发作的严重程度时使用了如峰值流量计等客观测量方法。治疗急性发作的首选药物是每20分钟雾化吸入一次β-激动剂(81.8%)。虽然93%的人表示他们曾使用氨茶碱治疗急性发作,但大多数人会将该药物留给症状严重的患者。皮质类固醇仅用于严重发作的患者(门诊和住院患者均为91.7%)。氢化可的松是最常用的皮质类固醇制剂(59.8%)。97%的人在治疗急性哮喘时使用抗生素,但仅在有适当指征时使用。对于慢性哮喘,观察到强烈倾向于选择口服β-激动剂作为首选支气管扩张剂(88%)。对于中度至重度哮喘患者,41%的受访者仍首选氨茶碱。在预防药物中,酮替芬是最受青睐的药物(90.4%),而吸入性类固醇和色甘酸钠的选择率分别为9.6%和2.4%。85%的人表示他们会开具为期1年或更短时间的预防药物。42%的人从未将过敏评估视为儿童哮喘检查的一部分。在泰国儿科医生中观察到了儿童哮喘管理的某些处方习惯,即:1)儿科医生在评估哮喘严重程度时使用客观测量方法的频率较低;2)在治疗急性哮喘时频繁使用氨茶碱和抗生素;3)在治疗急性哮喘时较晚使用皮质类固醇;4)倾向于口服支气管扩张剂;5)倾向于选择酮替芬作为首选预防药物。这项调查提供了基线数据,并将有助于评估泰国儿童哮喘的管理指南。

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