TTS-ST93-1穴位贴剂治疗晕动病的效果研究

[Study on effect of acupoint sticker of TTS-ST93-1 in treating motion sickness].

作者信息

Pei J, Yang T, Liu Z

机构信息

Institute of Space Medco-Engineering, Beijing 100094.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Aug;18(8):464-7.

PMID:11477828

Abstract

OBJECTIVE

To observe the effect of Transdermal Therapeutic System ST93-1 (TTS-ST93-1) by acupoint sticking in treating motion sickness (MS).

METHODS

One hundred and sixty-three young volunteers with history of MS recently were subjected to a 3 hours journey by track and armored car, and divided randomly into tested, positive control and negative control groups, treated with TTS-ST93-1 plaster, TTS-Scopolamine plaster and placebo (lactose plaster) respectively. The TTS-ST93-1 plaster was stuck on Neiguan (P6) or Shenque (CV8) or Qimai (TE18) point and the effect of treatment was observed by double-blind method.

RESULTS

The mean effective rate of tested group was 95.9%, which was significantly different to that of the negative control group (P < 0.01). In the tested group, the protection rate of plaster stuck on Shenque was 81.4%, on Neiguan was 45.5% and on Qimai was 100%, with an average of 76.0%, which was significantly different to that of the negative control group. The protection rate of TTS-Scopolamine plaster was merely 27.3%. The side effects of TTS-ST93-1 plaster were mouth dryness, sleepiness and fatigue, as compared with the negative control group, the difference was insignificant. No allergic reaction of skin such as swelling, pain or itching was found in the tested group.

CONCLUSION

Acupoint sticker of TTS-ST93-1 was an effective treatment for MS with less side effect and no allergic reaction of skin.

摘要

目的

观察经皮治疗系统ST93-1（TTS-ST93-1）穴位贴敷治疗晕动病（MS）的效果。

方法

163名近期有晕动病史的青年志愿者乘坐履带式装甲车进行3小时行程，随机分为试验组、阳性对照组和阴性对照组，分别用TTS-ST93-1贴膏、东莨菪碱贴膏和安慰剂（乳糖贴膏）治疗。TTS-ST93-1贴膏贴于内关（P6）、神阙（CV8）或七脉（TE18）穴，采用双盲法观察治疗效果。

结果

试验组平均有效率为95.9%，与阴性对照组差异有统计学意义（P<0.01）。试验组中，贴于神阙穴的保护率为81.4%，内关穴为45.5%，七脉穴为100%，平均为76.0%，与阴性对照组差异有统计学意义。东莨菪碱贴膏的保护率仅为27.3%。TTS-ST93-1贴膏的副作用为口干、嗜睡和疲劳，与阴性对照组相比，差异无统计学意义。试验组未发现皮肤肿胀、疼痛或瘙痒等过敏反应。