Wu Q, Duan L, Lin Y
Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149.
Zhonghua Jie He He Hu Xi Za Zhi. 1998 Oct;21(10):617-9.
Pharmacokinetics of INH, RFP and OFLX in serum and cold abscesses of patients with spinal tuberculosis was analyzed to provide reference to choosing clinical therapeutic regimen.
The aspiration specimens of abscesses and venous blood were collected from 8 patients with spinal tuberculosis at 0.5, 0.75, 1.0, 1.5, 2.0, 4.0, 6.0, 9.0, 12.0, 16.0 and 24.0 h after administration of antituberculous drugs. The specimens were assessed by high performance liquid chromatography (HPLC). The data were processed with software 3P87.
The Cmax of INH, RFP and OFLX in serum were 10.87 +/- 7.09 micrograms/ml, 9.98 +/- 3.53 micrograms/ml, and 5.29 +/- 0.72 micrograms/ml, while the Cmax of INH, RFP and OFLX in cold abscesses were 2.84 +/- 1.63 micrograms/ml, 0.57 +/- 0.26 microgram/ml and 3.19 +/- 1.29 micrograms/ml respectively.
After administration, the Cmax of INH and OFLX in the cold abscesses of patients with spinal tuberculosis, reached the level beyond their MIC and appeared and disappeared more slowly than that in the serum; RFP was not easy to permeate into the cold abscesses, the Cmax of RFP in the cold abscesses just reached its MIC.
分析异烟肼（INH）、利福平（RFP）和氧氟沙星（OFLX）在脊柱结核患者血清及寒性脓肿中的药代动力学，为临床治疗方案的选择提供参考。
收集8例脊柱结核患者在抗结核药物给药后0.5、0.75、1.0、1.5、2.0、4.0、6.0、9.0、12.0、16.0和24.0小时的脓肿穿刺标本及静脉血。采用高效液相色谱法（HPLC）对标本进行检测。数据用3P87软件处理。
INH、RFP和OFLX在血清中的Cmax分别为10.87±7.09微克/毫升、9.98±3.53微克/毫升和5.29±0.72微克/毫升，而INH、RFP和OFLX在寒性脓肿中的Cmax分别为2.84±1.63微克/毫升、0.57±0.26微克/毫升和3.19±1.29微克/毫升。
给药后，脊柱结核患者寒性脓肿中INH和OFLX的Cmax达到其MIC以上水平，且在脓肿中出现和消失的速度比在血清中更慢；RFP不易渗透到寒性脓肿中，寒性脓肿中RFP的Cmax刚达到其MIC。
