[Change of hymodynamics and circulating endothelial cells in chronic obstructive pulmonary diseases (COPD) and cor pulmonale patients].

OBJECTIVE

To investigate the vascular endothelial injuries by observing the changes of circulating endothelial cells (CEC) numbers in blood and hemodynamics in COPD and cor pulmonale patients.

METHOD

The arterial catheterion technique and CEC collection technique were used, superoxide dismutase (SOD) and malondialdyhyde(MDA) levels were determined respectively.

RESULT

mPAP (3.76 +/- 0.75 kPa) and CEC (16.70 +/- 2.65/0.9 microliter), MDA (6.98 +/- 1.47 mumol/L) in the chronic cor pulmonale are higher than that of mPAP (2.09 +/- 0.41 kPa) and CEC (8.48 +/- 2.23 microliters) in COPD, the numbers of CEC are adversely correlated to PaO2 (gamma = 0.9423, P < 0.001) and positively correlated with mPAP (gamma = 0.8270, P < 0.001), superoxide dismutase(SOD) was decreased.

CONCLUSION

mPAP, CEC are higher in cor pulmonale than that in COPD, CEC numbers rise when the PaO2 was lowered, hypoxia may worsen the vascular endothelial injuries.