[慢性阻塞性肺疾病继发慢性肺源性心脏病患者的血流动力学变化及硝普钠给药的影响]
[Hemodynamic changes in patients with chronic cor pulmonale secondary to COPD and effect of sodium nitroprusside administration].
作者信息
Wang H Y, Zhang H Y, Weng X Z
机构信息
Beijing Respiratory Disease Research Division, Beijing Red Cross Chaoyang Hospital.
出版信息
Zhonghua Nei Ke Za Zhi. 1991 Mar;30(3):141-3, 187.
Pulmonary hemodynamic changes were studied with Swan-Ganz right heart catheterization in 19 patients with chronic cor pulmonale secondary to COPD. HR, RVP, PAPM, PVR, PCWP, RWI and PaCO2 were significantly higher and PaO2 and PH lower in patients with decompensated than those with compensated heart function. Nitroprusside lowered effectively pulmonary arterial pressure and pulmonary vascular resistance. Meanwhile, the drug also lowered PaO2 when the patient was breathing air but did not so or even increased it when breathing oxygen.
对19例慢性阻塞性肺疾病（COPD）继发慢性肺心病患者采用Swan-Ganz右心导管检查法研究其肺血流动力学变化。与心功能代偿患者相比，失代偿患者的心率（HR）、右心室压力（RVP）、平均肺动脉压（PAPM）、肺血管阻力（PVR）、肺毛细血管楔压（PCWP）、右心室做功指数（RWI）及动脉血二氧化碳分压（PaCO2）显著升高，而动脉血氧分压（PaO2）及pH值降低。硝普钠可有效降低肺动脉压和肺血管阻力。同时，该药物在患者呼吸空气时会降低PaO2，但在患者吸氧时不会降低甚至会使其升高。
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