Malhotra M S, Brahmachari H D, Sridharan K, Purshottam T, Ramachandran K, Radhakrishnan U
Aviat Space Environ Med. 1975 Apr;46(4 Sec 1):409-12.
Ten normal healthy male subjects between 20-30 years of age were initially examined at Delhi (200 m) and thereafter air-lifted to an altitude of 3,500 m. Excretion of sodium, potassium and chloride in urine and their plasma level were determined at sea level (SL) and daily at high altitude (HA) for 4 d. At HA, four subjects developed high-altitude pulmonary edema (HAPE), four remained normal, and two suffered from acute mountain sickness. The results on normals and HAPE are presented. There was increased excretion of potassium at HA in both groups resulting in reduction of plasma level. The sodium and chloride excretion was also increased in normals at HA irrespective of urine volume. In HAPE cases, the sodium and chloride excretion was related to urine output. With the retention of fluid, the excretion of these ions in urine was diminished without a parallel change in plasma levels.
10名年龄在20至30岁之间的正常健康男性受试者最初在德里（海拔200米）接受检查，随后被空运至海拔3500米处。在海平面（SL）以及在高海拔（HA）处每日测定尿中钠、钾和氯的排泄量及其血浆水平，持续4天。在高海拔处，4名受试者发生了高原肺水肿（HAPE），4名保持正常，2名患有急性高山病。呈现了正常人和高原肺水肿患者的结果。两组在高海拔处钾的排泄均增加，导致血浆水平降低。在高海拔处，无论尿量多少，正常人的钠和氯排泄也增加。在高原肺水肿病例中，钠和氯的排泄与尿量有关。随着液体潴留，这些离子在尿中的排泄减少，而血浆水平无相应变化。
