Cave D R
Division of Gastroenterology, St. Elizabeth's Medical Center, Brighton, MA, USA.
Semin Gastrointest Dis. 2001 Jul;12(3):196-202.
Helicobacter pylori is the major cause of chronic gastritis. The predominant anatomic distribution of the gastritis is antral in the majority of individuals. In a small minority, the corpus is predominantly involved. The former pattern is associated with duodenal ulceration in some patients, but the majority of those infected never develop either symptoms or disease. The latter form is associated with the development of gastric ulcer and carcinoma and may be protective against the development of Barrett's esophagus. It is the physiological changes associated with the histological changes and the, as yet poorly, defined host response, which are of paramount importance in determining the evolution of a disease or whether the infected individual remains asymptomatic and disease free. This article addresses the various relationships between H. pylori infection, histology, gastric physiology, and disease.
幽门螺杆菌是慢性胃炎的主要病因。在大多数个体中，胃炎的主要解剖分布部位是胃窦。少数情况下，胃体是主要受累部位。前一种模式在一些患者中与十二指肠溃疡有关，但大多数感染者既没有症状也没有发病。后一种形式与胃溃疡和胃癌的发生有关，可能对巴雷特食管的发生有保护作用。与组织学变化相关的生理变化以及尚未明确的宿主反应，在决定疾病的发展或感染者是否保持无症状和无疾病状态方面至关重要。本文探讨了幽门螺杆菌感染、组织学、胃生理学和疾病之间的各种关系。
