加山地区儿童哮喘与幽门螺杆菌相关性评估

Evaluation of the Correlation Between Childhood Asthma and Helicobacter pylori in Kashan.

作者信息

Khamechian Tahere, Movahedian Amir Hossein, Ebrahimi Eskandari Ghasem, Heidarzadeh Arani Marzieh, Mohammadi Abouzar

机构信息

Anatomical Sciences Research Centre, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IR Iran.

Pediatric Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.

出版信息

Jundishapur J Microbiol. 2015 Jun 1;8(6):e17842. doi: 10.5812/jjm.8(6)2015.17842. eCollection 2015 Jun.

DOI:10.5812/jjm.8(6)2015.17842

PMID:26310565

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4545572/

Abstract

BACKGROUND

Asthma is a chronic inflammatory air-way disease with increasing prevalence rate during the recent years. There are studies about the relationship between asthma and infectious diseases, including the association between asthma and Helicobacter pylori. According to the latest studies, there is an epidemiological correlation between asthma prevalence and prevalence of H. pylori.

OBJECTIVES

The aim of this research was to study the correlation between H. pylori and asthma by biopsy in five to eighteen year-old children who had undergone endoscopy at Shahid Beheshti Hospital.

PATIENTS AND METHODS

Three hundred children (5 to 18 years old) undergoing endoscopy owing to gastro-intestinal problems at Shahid Beheshti Hospital were observed for childhood asthma using the Gina 2010 questionnaire which included 24 questions with "yes" and "no" answers to identify asthmatic patients with five positive answers. Next, the patients were referred to an allergy and asthma specialist for clinical examinations, spirometry and post bronchodilator test (Post BD).

RESULTS

Among 138 H. pylori positive patients, eight cases (5.8 %) were asthmatic while of the 162 H. pylori negative patients 28 (17.3%) were asthmatic. This difference was statistically significant (P Value = 0.002). The correlation between H. pylori and asthma was studied after controlling the confounding variables including, gender, age and family history. The results obtained for the above-mentioned variables were significant (P Values of 0.004, 0.005 and 0.002, and Odd-Ratio Mantel Haenszel (ORMH) of 3.38, 3.24 and 4.06, respectively).

CONCLUSIONS

Our findings showed that there is an inverse correlation between H. pylori and asthma. Performing more studies with larger sample sizes is necessary to confirm these results.

摘要

背景

哮喘是一种慢性炎症性气道疾病，近年来患病率不断上升。有关于哮喘与传染病之间关系的研究，包括哮喘与幽门螺杆菌之间的关联。根据最新研究，哮喘患病率与幽门螺杆菌患病率之间存在流行病学相关性。

目的

本研究的目的是通过对在沙希德·贝赫什提医院接受内镜检查的5至18岁儿童进行活检，研究幽门螺杆菌与哮喘之间的相关性。

患者与方法

对在沙希德·贝赫什提医院因胃肠道问题接受内镜检查的300名儿童（5至18岁），使用2010年吉娜问卷观察儿童哮喘情况，该问卷包含24个有“是”和“否”答案的问题，以识别有5个阳性答案的哮喘患者。接下来，患者被转介给过敏和哮喘专科医生进行临床检查、肺功能测定和支气管扩张剂后测试（支气管扩张剂后测试）。

结果

在138例幽门螺杆菌阳性患者中，8例（5.8%）患有哮喘，而在162例幽门螺杆菌阴性患者中，28例（17.3%）患有哮喘。这种差异具有统计学意义（P值=0.002）。在控制包括性别、年龄和家族史等混杂变量后，研究了幽门螺杆菌与哮喘之间的相关性。上述变量的结果具有显著性（P值分别为0.004、0.005和0.002，Mantel Haenszel比值比（ORMH）分别为3.38、3.24和4.06）。