Dion R, Glineur D, Derouck D, Verhelst R, Noirhomme P, El Khoury G, Degrave E, Hanet C
Cliniques Universitaires Saint-Luc, Brussels, Belgium.
J Thorac Cardiovasc Surg. 2001 Aug;122(2):296-304. doi: 10.1067/mtc.2001.115419.
Recently we reviewed the 10-year clinical and angiographic outcomes of sequential internal thoracic artery grafting. Most of the patients also received complementary saphenous grafts, and their overall long-term patency rates were surprisingly high. Therefore, we decided to analyze these results in more detail.
The first consecutive 500 patients having received at least one sequential internal thoracic artery graft between October 1985 and August 1991 were restudied retrospectively. The saphenous grafts were only used to achieve complete revascularization in addition to complex arterial grafting on less significant or remote coronary vessels. A total of 161 patients consented to a late angiographic restudy at a mean postoperative interval of 7.5 years (1-12.2 years).
At 5 and 10 years postoperatively, freedom from angina was 96% and 82%, and freedom from any cardiac event was 92.8% and 69%, respectively. Only 15 (3.1%) patients needed additional revascularization (0.3% per patient-year): 4 coronary artery bypass grafting (0.8%) and 11 percutaneous transluminal coronary angioplasty (2.3%). The overall patency and intactness rates of saphenous anastomoses were 72.5% and 60.2%, respectively. There was a significant difference between the patency and intactness of sequential versus single anastomoses: 76% versus 60% and 64.5% versus 44.4%, respectively. There was no significant difference in either patency or intactness between right internal thoracic and sequential saphenous grafts anastomosed to the right coronary artery: 83.4% versus 75.2% and 77.8% versus 62.4%, respectively. The same was true for the anastomoses to the "remote area" (distal circumflex, distal right coronary artery).
Complementary sequential saphenous grafting still deserves consideration in some patients below 70 years of age, particularly for those with disease in the "remote area": the distal circumflex and right coronary branches.
最近我们回顾了序贯胸廓内动脉移植的10年临床和血管造影结果。大多数患者还接受了辅助性大隐静脉移植,其总体长期通畅率出奇地高。因此,我们决定更详细地分析这些结果。
对1985年10月至1991年8月期间连续接受至少一次序贯胸廓内动脉移植的首批500例患者进行回顾性研究。大隐静脉移植仅用于在对不太重要或较远的冠状动脉血管进行复杂动脉移植之外实现完全血运重建。共有161例患者同意在术后平均7.5年(1 - 12.2年)时进行晚期血管造影复查。
术后5年和10年时,无心绞痛发生率分别为96%和82%,无任何心脏事件发生率分别为92.8%和69%。仅15例(3.1%)患者需要再次血运重建(每年每例患者0.3%):4例行冠状动脉旁路移植术(0.8%),11例行经皮冠状动脉腔内血管成形术(2.3%)。大隐静脉吻合口的总体通畅率和完整性率分别为72.5%和60.2%。序贯吻合与单支吻合的通畅率和完整性存在显著差异:分别为76%对60%和64.5%对44.4%。吻合至右冠状动脉的右胸廓内动脉与序贯大隐静脉移植在通畅率或完整性方面均无显著差异:分别为83.4%对75.2%和77.8%对62.4%。吻合至“偏远区域”(旋支远端、右冠状动脉远端)的情况也是如此。
对于一些70岁以下的患者,尤其是那些“偏远区域”(旋支远端和右冠状动脉分支)有病变的患者,辅助性序贯大隐静脉移植仍值得考虑。