Reichler I M, Hoerauf A, Guscetti F, Gardelle O, Stoffel M H, Jentsch B, Walt H, Arnold S
Department of Reproduction, Faculty of Veterinary Medicine, University of Zurich, Switzerland.
J Small Anim Pract. 2001 Jul;42(7):345-8. doi: 10.1111/j.1748-5827.2001.tb02471.x.
A nine-month-old golden retriever bitch was presented with exercise intolerance and recurrent nasal discharge. Based on clinical, radiographic and ultrasonographic examination, a diagnosis of rhinitis, situs inversus totalis and tricuspid valve insufficiency was established. The results of video- and electron microscopy studies of the respiratory epithelium were compatible with primary ciliary dyskinesia (PCD). However, no evidence of a primary ultrastructural defect of the cilia was found. The dog was euthanased because of the poor prognosis. At necropsy, a hydrocephalus internus and a subaortic stenosis were additionally diagnosed. PCD, in combination with situs inversus, has been previously reported in golden retrievers, but without a concomitant hydrocephalus internus. Furthermore, concomitant occurrence of internal cardiac malformation and PCD has not previously been reported in the dog.
一只九个月大的金毛猎犬母犬出现运动不耐受和反复鼻分泌物增多的症状。基于临床、放射学和超声检查，诊断为鼻炎、完全性内脏反位和三尖瓣关闭不全。呼吸道上皮的视频显微镜和电子显微镜研究结果与原发性纤毛运动障碍（PCD）相符。然而，未发现纤毛原发性超微结构缺陷的证据。由于预后不良，该犬被实施安乐死。尸检时，另外诊断出脑积水和主动脉下狭窄。PCD与内脏反位同时出现此前在金毛猎犬中有过报道，但未伴有脑积水。此外，犬类中心脏内部畸形与PCD同时出现此前未见报道。
