Rodgers J B
Biochim Biophys Acta. 1975 Jul 22;398(1):92-100. doi: 10.1016/0005-2760(75)90172-1.
The role of biliary or dietary phosphatidylcholine (lecithin) in the process of lipid absorption was studied in bile fistual rats. Jejunal lipid-reesterifying enzyme activities were determined in experimental rats given diet, bile salts and phosphatidylethanolamine and results compared to controls given diet alone. Lipid absorption was also studied in vivo with radioactive techniques. Two groups of bile tistula rats were used. Both received diet and bile salts. In addition, one group was given phosphatidylethanolamine and the other received lecithin. Enzyme activities were moderately but significantly reduced in bile tistula rats receiving phosphatidylethanolamine. This was associated with an abnormal phospholipid composition of the microsomal membrane. Despite the changes in mucosal enzyme activity, however, no abnormality of lipid absorption was noted in bile fistula rats that received phosphatidylethanalamine. Results in this group were similar to controls and to the other bile fistula group given lecithin. In all groups, significant amounts of lecithin were recovered from the lumen of the small bowel. It is concluded that if lecithin is required for lipid absorption, it does not have to be supplied to the small bowel via the diet or in bile.
在胆瘘大鼠中研究了胆汁或膳食中的磷脂酰胆碱（卵磷脂）在脂质吸收过程中的作用。对给予饮食、胆盐和磷脂酰乙醇胺的实验大鼠测定空肠脂质再酯化酶活性，并将结果与仅给予饮食的对照组进行比较。还采用放射性技术在体内研究脂质吸收。使用了两组胆瘘大鼠。两组均给予饮食和胆盐。此外，一组给予磷脂酰乙醇胺，另一组给予卵磷脂。接受磷脂酰乙醇胺的胆瘘大鼠的酶活性适度但显著降低。这与微粒体膜磷脂组成异常有关。然而，尽管粘膜酶活性发生了变化，但接受磷脂酰乙醇胺的胆瘘大鼠未发现脂质吸收异常。该组的结果与对照组以及给予卵磷脂的另一组胆瘘大鼠相似。在所有组中，从小肠腔中回收了大量卵磷脂。得出的结论是，如果脂质吸收需要卵磷脂，则不必通过饮食或胆汁将其供应至小肠。
