氢化可的松和地塞米松对离体大鼠比目鱼肌木糖摄取的影响。

Effect of hydrocortisone and dexamethasone on xylose uptake by isolated rat soleus muscle.

作者信息

Chaudry I H, Adzick N S, Sayeed M M, Baue A E

出版信息

Biochim Biophys Acta. 1975 Jul 14;399(1):85-9. doi: 10.1016/0304-4165(75)90214-7.

Abstract

To determine the effects of glucocorticoids on sugar uptake, xylose uptake by isolated rat soleus muscle of bilaterally adrenalectomized animals was studied. The results indicate that in vitro addition of 10-4 M hydrocortisone, dexamethasone or hydrocortisone sodium succinate had no inhibitory effect on basal xylose uptake. In the presence of both low and high medium insulin, the above steroids failed to inhibit insulin-stimulated uptake. When the concentration of hydrocortisone sodium succinate was increased to 10-2 M, insulinstimulated uptake was decreased. The results thus indicate that glucocorticoids at concentrations observed under physiological or pathological conditions do not inhibit basal or insulin-stimulated sugar uptake.

摘要

为了确定糖皮质激素对糖摄取的影响，研究了双侧肾上腺切除动物的离体大鼠比目鱼肌对木糖的摄取。结果表明，在体外添加10-4 M氢化可的松、地塞米松或氢化可的松琥珀酸钠对基础木糖摄取没有抑制作用。在低浓度和高浓度胰岛素存在的情况下，上述类固醇未能抑制胰岛素刺激的摄取。当氢化可的松琥珀酸钠的浓度增加到10-2 M时，胰岛素刺激的摄取减少。因此，结果表明，在生理或病理条件下观察到的糖皮质激素浓度不会抑制基础或胰岛素刺激的糖摄取。