儿童及其父母的胆固醇筛查。

Cholesterol screening among children and their parents.

作者信息

Muratova V N, Islam S S, Demerath E W, Minor V E, Neal W A

机构信息

Department of Pediatrics, West Virginia University School of Medicine, Morgantown 26506, USA.

出版信息

Prev Med. 2001 Jul;33(1):1-6. doi: 10.1006/pmed.2001.0855.

DOI:10.1006/pmed.2001.0855

PMID:11482989

Abstract

BACKGROUND

The Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) project is designed to test the hypothesis that universal cholesterol screening of prepubertal schoolchildren is effective in identifying children and their parents at risk of developing premature coronary heart disease (CHD) in a high-risk rural population.

METHODS

Seven hundred nine fifth-grade schoolchildren from seven rural Appalachian counties participated in a school-based cholesterol screening program. Family history of premature CHD, anthropometric and blood pressure measurement, tobacco smoke exposure, dietary history, and physical activity levels were collected.

RESULTS

One-fourth (174) of the children were "presumptively" dyslipidemic upon measurement of nonfasting finger-stick blood cholesterol (FSC). Subsequent fasting lipid profile obtained for 63 of these children and 79 of their parents confirmed the presence of dyslipidemia in 37 children (59%) and 52 parents (66%). Among confirmed dyslipidemic children, family history was not a good predictor of dyslipidemia (sensitivity 21.6%). FSC levels were significantly correlated with fasting total cholesterol of children and their parents.

CONCLUSIONS

Universal nonfasting FSC screening of prepubertal schoolchildren is effective in identifying dyslipidemic children and their parents, whereas family history has low sensitivity in predicting children with elevated blood cholesterol concentrations.

摘要

背景

阿巴拉契亚社区冠状动脉风险检测（CARDIAC）项目旨在检验以下假设：对青春期前学童进行普遍的胆固醇筛查，对于识别高危农村人口中存在患早发性冠心病（CHD）风险的儿童及其父母是有效的。

方法

来自七个阿巴拉契亚农村县的709名五年级学童参与了一项基于学校的胆固醇筛查项目。收集了早发性冠心病家族史、人体测量数据、血压测量值、烟草烟雾暴露情况、饮食史和身体活动水平。

结果

在测量非空腹指尖血胆固醇（FSC）时，四分之一（174名）儿童“推测”为血脂异常。随后为其中63名儿童及其79名父母进行了空腹血脂检查，证实37名儿童（59%）和52名父母（66%）存在血脂异常。在确诊为血脂异常的儿童中，家族史并非血脂异常的良好预测指标（敏感性为21.6%）。FSC水平与儿童及其父母的空腹总胆固醇显著相关。