The receptor for tetrodotoxin and saxitoxin. A structural hypothesis.
作者信息
Hille B
出版信息
Biophys J. 1975 Jun;15(6):615-9. doi: 10.1016/S0006-3495(75)85842-5.
Abstract
摘要
相似文献
1
The receptor for tetrodotoxin and saxitoxin. A structural hypothesis.河豚毒素和石房蛤毒素的受体。一种结构假说。
Biophys J. 1975 Jun;15(6):615-9. doi: 10.1016/S0006-3495(75)85842-5.
2
Different receptors for saxitoxin and tetrodotoxin [proceedings].沙蚕毒素和河豚毒素的不同受体[会议论文集]
J Physiol. 1978 Nov;284:88P-89P.
3
Multiple saxitoxin-binding sites in bullfrog muscle: tetrodotoxin-sensitive sodium channels and tetrodotoxin-insensitive sites of unknown function.
Mol Pharmacol. 1988 Feb;33(2):202-11.
4
Identification and properties of voltage-sensitive sodium channels in smooth muscle cells from pregnant rat myometrium.孕鼠子宫肌层平滑肌细胞电压敏感性钠通道的鉴定及特性
Mol Pharmacol. 1990 Nov;38(5):667-73.
5
The search for functional correspondences in molecular structure between two dissimilar molecules.寻找两个不同分子之间分子结构中的功能对应关系。
J Theor Biol. 1985 Sep 21;116(2):215-24. doi: 10.1016/s0022-5193(85)80265-4.
6
Chemistry and biochemistry of saxitoxin analogues and tetrodotoxin.
Ann N Y Acad Sci. 1986;479:24-31. doi: 10.1111/j.1749-6632.1986.tb15558.x.
7
A rapid and precise assay for tetrodotoxin binding to detergent extracts of excitable tissues.一种用于检测河豚毒素与可兴奋组织去污剂提取物结合的快速且精确的分析方法。
Anal Biochem. 1979 Oct 15;99(1):72-84. doi: 10.1016/0003-2697(79)90045-9.
8
A pharmacological approach to the structure of sodium channels in myelinated axons.
Annu Rev Neurosci. 1979;2:341-62. doi: 10.1146/annurev.ne.02.030179.002013.
9
Kinetics of tetrodotoxin and saxitoxin action at the node of Ranvier.河豚毒素和石房蛤毒素在郎飞结处的作用动力学
Adv Cytopharmacol. 1979;3:363-71.
10
Mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of the puffer fish, Fugu pardalis.
Biosci Biotechnol Biochem. 2002 Nov;66(11):2520-4. doi: 10.1271/bbb.66.2520.
引用本文的文献
1
Three-dimensional Quantitative Structure-activity Relationship, Molecular Docking and Absorption, Distribution, Metabolism, and Excretion Studies of Lidocaine Analogs Pertaining to Voltage-gated Sodium Channel Na1.7 Inhibition for the Management of Neuropathic Pain.利多卡因类似物与电压门控钠通道Na1.7抑制作用相关的三维定量构效关系、分子对接及吸收、分布、代谢和排泄研究，用于治疗神经性疼痛
Int J Appl Basic Med Res. 2025 Jul-Sep;15(3):143-151. doi: 10.4103/ijabmr.ijabmr_347_24. Epub 2025 Aug 20.
2
A structural atlas of druggable sites on Na channels.钠离子通道可成药性位点的结构图谱。
Channels (Austin). 2024 Dec;18(1):2287832. doi: 10.1080/19336950.2023.2287832. Epub 2023 Nov 30.
3
Physiological Effects of Oxidative Stress Caused by Saxitoxin in the Nematode .氧化应激对线虫中石房蛤毒素的生理影响
Mar Drugs. 2023 Oct 19;21(10):544. doi: 10.3390/md21100544.
4
Structural Basis for High-Affinity Trapping of the Na1.7 Channel in Its Resting State by Tarantula Toxin.蜘蛛毒素以高亲和力将钠离子通道 1.7 亚型捕获于静息状态的结构基础
Mol Cell. 2021 Jan 7;81(1):38-48.e4. doi: 10.1016/j.molcel.2020.10.039. Epub 2020 Nov 23.
5
Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods.海洋双壳贝类和腹足类动物中存在河豚毒素（TTX）及TTX类似物对公众健康造成的风险。
EFSA J. 2017 Apr 20;15(4):e04752. doi: 10.2903/j.efsa.2017.4752. eCollection 2017 Apr.
6
Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor.泽替毒素 AB 的合成方法，一种有效的电压门控钠离子通道抑制剂。
Mar Drugs. 2019 Dec 26;18(1):24. doi: 10.3390/md18010024.
7
Structure of the Cardiac Sodium Channel.心脏钠离子通道的结构。
Cell. 2020 Jan 9;180(1):122-134.e10. doi: 10.1016/j.cell.2019.11.041. Epub 2019 Dec 19.
8
Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media.经鼓室给予局部麻醉药治疗急性中耳炎疼痛。
Mol Pharm. 2019 Apr 1;16(4):1555-1562. doi: 10.1021/acs.molpharmaceut.8b01235. Epub 2019 Mar 6.
9
Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies.基于动物毒素研究预测钠通道孔的结构细节
Front Pharmacol. 2018 Aug 7;9:880. doi: 10.3389/fphar.2018.00880. eCollection 2018.
10
A perspective on Na and K channel inactivation.钠离子和钾离子通道失活机制的研究进展
J Gen Physiol. 2018 Jan 2;150(1):7-18. doi: 10.1085/jgp.201711835. Epub 2017 Dec 12.
本文引用的文献
1
Biochemical studies on paralytic shellfish poisons.麻痹性贝类毒素的生化研究。
Ann N Y Acad Sci. 1960 Nov 17;90:843-55. doi: 10.1111/j.1749-6632.1960.tb26427.x.
2
Comparison of tetrodotoxin and procaine in internally perfused squid giant axons.河豚毒素与普鲁卡因在鱿鱼巨轴突内灌注中的比较。
J Gen Physiol. 1967 May;50(5):1413-28. doi: 10.1085/jgp.50.5.1413.
3
Potency difference between the zwitterion form and the cation forms of tetrodotoxin.河豚毒素两性离子形式与阳离子形式之间的效价差异。
Science. 1967 Jun 23;156(3782):1625-7. doi: 10.1126/science.156.3782.1625.
4
Tetrodotoxin derivatives: chemical structure and blockage of nerve membrane conductance.河豚毒素衍生物：化学结构与神经膜电导的阻断
Science. 1967 May 19;156(3777):976-9. doi: 10.1126/science.156.3777.976.
5
Pharmacological modifications of the sodium channels of frog nerve.青蛙神经钠通道的药理学修饰
J Gen Physiol. 1968 Feb;51(2):199-219. doi: 10.1085/jgp.51.2.199.
6
Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena.河豚毒素、石房蛤毒素及其在兴奋现象研究中的意义。
Pharmacol Rev. 1966 Jun;18(2):997-1049.
7
The permeability of the sodium channel to organic cations in myelinated nerve.有髓神经中钠通道对有机阳离子的通透性。
J Gen Physiol. 1971 Dec;58(6):599-619. doi: 10.1085/jgp.58.6.599.
8
The rate of action of tetrodotoxin on myelinated nerve fibres of Xenopus laevis and Rana esculenta.河豚毒素对非洲爪蟾和食用蛙有髓神经纤维的作用速率。
J Physiol. 1973 Aug;233(1):167-94. doi: 10.1113/jphysiol.1973.sp010304.
9
Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane.河豚毒素和石房蛤毒素作用于神经膜钠通道中金属阳离子结合位点的证据。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3936-40. doi: 10.1073/pnas.71.10.3936.
10
Tetrodotoxin, saxitoxin, and related substances: their applications in neurobiology.河豚毒素、石房蛤毒素及相关物质：它们在神经生物学中的应用。
Int Rev Neurobiol. 1972;15:83-166. doi: 10.1016/s0074-7742(08)60329-3.
Zotero 插件