[细胞色素P450 1A1基因多态性与早发性帕金森病易感性]
[Genetic polymorphisms of cytochrome P450 1A1 and susceptibility of early-onset Parkinson's disease].
作者信息
Liu P, Liu Z, Shao M, Chen B
机构信息
Department of Neurology, Zhujiang Hospital, the First Military Medical University, Guangzhou, Guangdong 510282 P.R.China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001 Aug;18(4):283-5.
OBJECTIVE
To assess the possible association between the Msp I polymorphisms of cytochrome P450 1A1(CYP1A1) and the susceptibility of early-onset Parkinson's disease among Hans in the northern part of China.
METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze three genotypes A, B and C in 3'flanking region of CYP1A1 in 126 patients with idiopathic early-onset Parkinson's disease and 172 healthy controls.
RESULTS
The frequencies of genotypes A, B and C in patients were 41.3%, 43.6% and 15.1% while those in the controls were 34.9%, 51.7% and 13.4%, respectively. No statistically significant difference in the frequencies of the three genotypes was observed between the two groups. The frequencies of two alleles were of no significant difference between the patients and controls.
CONCLUSION
The above results suggest that the Msp I polymorphisms of cytochrome P450 1A1 itself might not be associated with idiopathic early-onset Parkinson's disease.
目的
评估中国北方汉族人群中细胞色素P450 1A1（CYP1A1）基因Msp I多态性与早发性帕金森病易感性之间的可能关联。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，分析126例特发性早发性帕金森病患者和172例健康对照者CYP1A1基因3'侧翼区的A、B、C三种基因型。
结果
患者中基因型A、B、C的频率分别为41.3%、43.6%和15.1%，对照组分别为34.9%、51.7%和13.4%。两组间三种基因型频率无统计学显著差异。患者与对照组两个等位基因的频率无显著差异。
结论
上述结果提示，细胞色素P450 1A1基因的Msp I多态性本身可能与特发性早发性帕金森病无关。
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