[广东省汉族女性子宫内膜异位症易感性与细胞色素P450 1A1基因Msp I多态性的相关性]
[Susceptibility to endometriosis in women of Han Nationality in Guangdong Province associated with Msp I polymorphisms of cytochrome P450 1A1 gene].
作者信息
Peng Dong-xian, He Yuan-li, Qiu Li-wen, Yang Fang, Lin Jing-ming
机构信息
Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2002 Sep;22(9):814-6.
OBJECTIVE
To assess the possible association of the Msp I polymorphisms of cytochrome P4501A1(CYP1A1) gene with the susceptibility to endometriosis in women of Han Nationality in Guangdong Province.
METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to analyze the 3 genotypes m1m1, m1m2 and m2m2 in 3'-flanking region of CYP1A1 in 76 patients with endometriosis and 80 healthy controls.
RESULTS
The frequencies of genotypes m1m1, m1m2 and m2m2 were 30.3 %, 50.0 % and 19.7 % in patients with endometriosis while 42.5 %, 45.0 % and 12.5 % in the controls, respectively, showing no statistically significant difference in the frequencies of the three genotypes between the 2 groups. The frequencies of two alleles were of no significant difference between the patients and controls, either.
CONCLUSION
Msp I polymorphisms of cytochrome P4501A1 in itself might not be associated with the susceptibility to endometriosis in women of Han Nationality in Guangdong Province.
目的
评估细胞色素P4501A1（CYP1A1）基因Msp I多态性与广东省汉族女性子宫内膜异位症易感性之间的可能关联。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术分析76例子宫内膜异位症患者和80例健康对照者CYP1A1基因3'侧翼区的m1m1、m1m2和m2m2三种基因型。
结果
子宫内膜异位症患者中m1m1、m1m2和m2m2基因型频率分别为30.3%、50.0%和19.7%，对照组分别为42.5%、45.0%和12.5%，两组间三种基因型频率差异无统计学意义。两组患者两个等位基因频率差异也无统计学意义。
结论
细胞色素P4501A1的Msp I多态性本身可能与广东省汉族女性子宫内膜异位症易感性无关。
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