Marinculić A, Fajdiga M, Duraković E
Veterinary Faculty, University of Zagreb, Croatia.
Parasite. 2001 Jun;8(2 Suppl):S191-4. doi: 10.1051/parasite/200108s2191.
A trial was undertaken to assess the efficacy of flubendazole against experimentally induced trichinellosis in pigs when given mixed with food at different dose rates. At the start of the experiment, 48 pigs were infected with approximately 35,000 larvae of Trichinella spiralis, afterwards the animals were distributed in six groups. The first three groups were used to test the activity of the drug against adult stages. Other three groups served to define the efficacy against muscle larvae. The dose rate of flubendazole varied according to the purpose of the experiment (from 8 mg/kg up to 62 mg/kg). At the end of the trial, the pigs were necropsied and the number of adults and larvae in predilection muscles were determined. At a dose rate of 8 mg/kg flubendazole supplied with food during eight days was 100% effective against adults. At a dose rate of 31 mg/kg flubendazole administered for 14 days was 72.35% effective. Treatment with higher dosages of flubendazole (62 mg/kg) resulted in increased efficacy (87.77%) against the parasites. The biological assay performed with larvae from the muscle samples originating from the pigs treated with 62 mg/kg showed that at least half of the larvae were not infective.
进行了一项试验，以评估氟苯达唑在以不同剂量率与食物混合投喂时，对实验诱导的猪旋毛虫病的疗效。实验开始时，48头猪感染了约35000条旋毛形线虫幼虫，之后将这些动物分成六组。前三组用于测试该药物对成虫阶段的活性。其他三组用于确定对肌幼虫的疗效。氟苯达唑的剂量率根据实验目的而有所不同（从8毫克/千克到62毫克/千克）。试验结束时，对猪进行尸检，并确定在其偏好寄生的肌肉中的成虫和幼虫数量。以8毫克/千克的剂量率在八天内与食物一起投喂氟苯达唑，对成虫的有效率为100%。以31毫克/千克的剂量率给药14天，有效率为72.35%。用更高剂量（62毫克/千克）的氟苯达唑进行治疗，对寄生虫的疗效有所提高（87.77%）。对用62毫克/千克治疗的猪的肌肉样本中的幼虫进行的生物学测定表明，至少一半的幼虫没有感染性。
