Moser M
Université libre de Bruxelles, Belgique.
Pathol Biol (Paris). 2001 Jul;49(6):450-3. doi: 10.1016/s0369-8114(01)00162-6.
Cells of the dendritic family are suited to perform two distinct functions at two discrete locations. In the peripheral tissues, DC act as sentinels for "dangerous" antigens. They then migrate into the lymphoid organ, where they initiate activation of T lymphocytes which are specific for these antigens. During their migration, DC shift from an antigen-capturing-mode to a T cell sensitizing mode. In addition to switching on the immune response, subtypes of DC appear to influence the character of T cell differentiation, i.e. the Th1/Th2 balance.
树突状细胞家族的细胞适合在两个不同的位置执行两种不同的功能。在外周组织中，树突状细胞作为“危险”抗原的哨兵。然后它们迁移到淋巴器官，在那里启动针对这些抗原的特异性T淋巴细胞的激活。在迁移过程中，树突状细胞从抗原捕获模式转变为T细胞致敏模式。除了开启免疫反应外，树突状细胞的亚型似乎还会影响T细胞分化的特征，即Th1/Th2平衡。
