Maldonado-López R, Moser M
Institut de Biologie et Médecine Moléculaires, Université Libre de Bruxelles, rue des Prof. Jeener et Brachet, 12, 6041 Gosselies, Belgium.
Semin Immunol. 2001 Oct;13(5):275-82. doi: 10.1006/smim.2001.0323.
Cells of the dendritic family are suited to perform two distinct functions at two discrete locations. In the peripheral tissues, dendritic cells (DC) act as sentinels for "dangerous" antigens. They then migrate into the lymphoid organ, where they initiate activation of T lymphocytes which are specific for these antigens. During their migration, DC shift from an antigen-capturing mode to a T cell sensitizing mode. In addition to switching on the immune response, subtypes of DC appear to influence the character of T cell differentiation, i.e. the Th1/Th2 balance. We will review the cellular and molecular bases of Th1-Th2 development by DC subsets, and will focus primarily, although not exclusively, on mouse DC.
树突状细胞家族的细胞适合在两个不同的位置执行两种不同的功能。在外周组织中，树突状细胞（DC）充当“危险”抗原的哨兵。然后它们迁移到淋巴器官，在那里启动针对这些抗原的特异性T淋巴细胞的激活。在迁移过程中，DC从抗原捕获模式转变为T细胞致敏模式。除了开启免疫反应外，DC的亚型似乎还会影响T细胞分化的特征，即Th1/Th2平衡。我们将综述DC亚群介导的Th1-Th2分化的细胞和分子基础，并且将主要关注（尽管不仅限于）小鼠DC。
