Koga M, Fujiwara M, Ariga S, Isumi H, Tashiro N, Matsubara T, Furukawa S
Department of Pediatrics, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.
Pediatr Pathol Mol Med. 2001 May-Jun;20(3):189-95.
We report two cases of fulminant viral myocarditis in previously healthy children. They were caused by herpes simplex virus (HSV)-1 (in a boy aged 3 years) and Epstein-Barr virus (EBV) (in a boy aged 12 months). We obtained the diagnosis of HSV-1 myocarditis by immunohistochemistry and the diagnosis of EBV myocarditis by in situ hybridization. Histologic examination of heart tissue from the two boys revealed mononuclear cell infiltration of the myocardium. Immunohistochemical staining identified these cells as CD8+ T-lymphocytes. CD8+ T-lymphocytes induced by herpes virus infections may play an important role in the damage to heart muscle fibers seen in fulminant myocarditis in previously healthy children. To our knowledge, this is the first report of HSV-1 or EBV myocarditis (at least in children) in which viral infection has been demonstrated in the myocardium.
我们报告了两例先前健康儿童的暴发性病毒性心肌炎病例。它们分别由单纯疱疹病毒1型（HSV-1，发生在一名3岁男孩身上）和爱泼斯坦-巴尔病毒（EBV，发生在一名12个月大的男孩身上）引起。我们通过免疫组织化学确诊了HSV-1心肌炎，通过原位杂交确诊了EBV心肌炎。对这两名男孩心脏组织的组织学检查显示心肌有单核细胞浸润。免疫组织化学染色将这些细胞鉴定为CD8+ T淋巴细胞。疱疹病毒感染诱导的CD8+ T淋巴细胞可能在先前健康儿童暴发性心肌炎中所见的心肌纤维损伤中起重要作用。据我们所知，这是首次报告在心肌中证实有病毒感染的HSV-1或EBV心肌炎（至少在儿童中）。
