Frangione B, Franklin E C
Nature. 1979 Oct 18;281(5732):600-2. doi: 10.1038/281600a0.
It is generally accepted that the variable (V) and constant (C) regions of immunoglobulin (Ig) chains are under separate genetic control. The notion that the different domains and interdomain regions are also under the control of independent genetic units was initially based on the clearcut results obtained by studying the primary structure of deletion mutants and received definitive support from direct analysis of cloned heavy (H) and light (L) chain genes. Here we present additional studies carried out on two selected gamma 3 deletion mutants which indicate the genetic control of human H chains may be even more complex than previously believed.
人们普遍认为，免疫球蛋白（Ig）链的可变（V）区和恒定（C）区受不同的基因控制。不同结构域和结构域间区域也受独立遗传单位控制这一观点，最初是基于对缺失突变体一级结构研究所得出的明确结果，并从对克隆的重（H）链和轻（L）链基因的直接分析中得到了确凿支持。在此，我们展示了对两个选定的γ3缺失突变体进行的额外研究，这些研究表明人类H链的基因控制可能比之前认为的更为复杂。
