Ryszka F, Dolinska B
Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, Sosnowiec, Poland.
Boll Chim Farm. 2001 May-Jun;140(3):169-71.
The influence of administration route of prolactin on its biological availability in rats was determined. Prolactin was administered intraperitoneally, intramuscularly and intranasally (intranasal inhalation) in single doses of 2.5 mg/kg body weight. Within 5 hours after the administration, there were noticed evident differences in prolactin concentrations in blood dependening on the route of administration. The maximal prolactin concentration after its intraperitoneal administration was 1.5 times as high as the maximal concentration observed for intramuscular or intranasal administration. The area under the curves: concentration: intraperitoneal administration time and concentration: intramuscular administration time was 132.99 ng/cm3/h and 136.28 ng/cm3/h, respetively. The area under the curve (AUC0-&) for the intranasal administration of prolactin was not much different than for the intraperitoneal and intramuscular ones, and was 111.30 ng/cm3/h.
测定了催乳素给药途径对其在大鼠体内生物利用度的影响。以2.5mg/kg体重的单剂量腹腔内、肌肉内和鼻内（经鼻吸入）给予催乳素。给药后5小时内，根据给药途径的不同，血液中催乳素浓度存在明显差异。腹腔内给药后催乳素的最大浓度是肌肉内或鼻内给药时观察到的最大浓度的1.5倍。曲线下面积：浓度：腹腔内给药时间和浓度：肌肉内给药时间分别为132.99ng/cm³/h和136.28ng/cm³/h。催乳素鼻内给药的曲线下面积（AUC0-∞）与腹腔内和肌肉内给药的曲线下面积差异不大，为111.30ng/cm³/h。
