Vancassel S, Durand G, Barthélémy C, Lejeune B, Martineau J, Guilloteau D, Andrès C, Chalon S
Laboratoire de Nutrition et Sécurité Alimentaire, INRA, domaine de Vilvert, 78352 Jouy-en-Josas cedex, France.
Prostaglandins Leukot Essent Fatty Acids. 2001 Jul;65(1):1-7. doi: 10.1054/plef.2001.0281.
Phospholipid fatty acids are major structural components of neuronal cell membranes, which modulate membrane fluidity and hence function. Evidence from clinical and biochemical sources have indicated changes in the metabolism of fatty acids in several psychiatric disorders. We examined the phospholipid fatty acids in the plasma of a population of autistic subjects compared to mentally retarded controls. Our results showed a marked reduction in the levels of 22: 6n-3 (23%) in the autistic subjects, resulting in significantly lower levels of total (n-3) polyunsaturated fatty acids (PUFA) (20%), without significant reduction in the (n-6) PUFA series, and consequently a significant increase in the (n-6)/(n-3) ratio (25%). These variations are discussed in terms of potential differences in PUFA dietary intake, metabolism, or incorporation into cellular membranes between the two groups of subjects. These results open up interesting perspectives for the investigation of new biological indices in autism. Moreover, this might have new therapeutic implications in terms of child nutrition.
磷脂脂肪酸是神经元细胞膜的主要结构成分，可调节膜流动性进而影响其功能。临床和生化研究证据表明，多种精神疾病中脂肪酸代谢存在变化。我们对一组自闭症受试者与智力发育迟缓对照组受试者的血浆磷脂脂肪酸进行了检测。我们的结果显示，自闭症受试者体内22:6n-3水平显著降低（23%），导致总（n-3）多不饱和脂肪酸（PUFA）水平显著降低（20%），而（n-6）PUFA系列水平无显著降低，因此（n-6）/（n-3）比值显著升高（25%）。从两组受试者在PUFA饮食摄入、代谢或整合到细胞膜方面的潜在差异对这些变化进行了讨论。这些结果为自闭症新生物学指标的研究开辟了有趣的前景。此外，这在儿童营养方面可能具有新的治疗意义。
